Functional and structural characterization of Deinococcus radiodurans R1 MazEF toxin-antitoxin system, Dr0416-Dr0417
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DOI: 10.1007/s12275-021-0523-z
Abstract: In prokaryotes, toxin-antitoxin (TA) systems are commonly found. They likely reflect the adaptation of pathogenic bacteria or extremophiles to various unfavorable environments by slowing their growth rate. Genomic analysis of the extremophile Deinococcus radiodurans R1… read more here.
Keywords: deinococcus radiodurans; toxin antitoxin; maze mazf; mazf ... See more keywords
Comparative analysis of MazEF and HicAB toxin–antitoxin systems of the cyanobacterium, Anabaena sp. PCC7120
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DOI: 10.1093/femsle/fnw279
Abstract: &NA; Anabaena PCC7120 has two annotated toxin–antitoxin systems: MazEF and HicAB. Overexpression of either of the toxins severely inhibited the growth of Escherichia coli BL21(plysS)(DE3). Of the two Anabaena toxins, MazF exhibited higher toxicity than… read more here.
Keywords: anabaena pcc7120; toxin; mazef hicab; toxin antitoxin ... See more keywords
MazF toxin causes alterations in Staphylococcus aureus transcriptome, translatome and proteome that underlie bacterial dormancy
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DOI: 10.1093/nar/gkaa1292
Abstract: Abstract Antibiotic resistance is a serious problem which may be caused by bacterial dormancy. It has been suggested that bacterial toxin–antitoxin systems induce dormancy. We analyzed the genome-wide role of Staphylococcus aureus endoribonuclease toxin MazF… read more here.
Keywords: staphylococcus aureus; dormancy; toxin; bacterial dormancy ... See more keywords
Insights into the global effect on Staphylococcus aureus growth arrest by induction of the endoribonuclease MazF toxin
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DOI: 10.1093/nar/gkaa617
Abstract: Abstract A crucial bacterial strategy to avoid killing by antibiotics is to enter a growth arrested state, yet the molecular mechanisms behind this process remain elusive. The conditional overexpression of mazF, the endoribonuclease toxin of… read more here.
Keywords: staphylococcus aureus; cleavage; growth arrest; toxin ... See more keywords
Conserved Amino Acid Moieties of Candidatus Desulforudis audaxviator MazF Determine Ribonuclease Activity and Specificity
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DOI: 10.3389/fmicb.2021.748619
Abstract: The toxin-antitoxin (TA) system, inherent to various prokaryotes, plays a critical role in survival and adaptation to diverse environmental stresses. The toxin MazF, belonging to the type II TA system, functions as a sequence-specific ribonuclease… read more here.
Keywords: ribonuclease; amino acid; candidatus desulforudis; mazf ... See more keywords