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Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800325
Abstract: A novel series of 30 symmetric bispyridinium and related N‐heteroaromatic bisquaternary salts with a propane‐1,3‐diyl linker was synthesized and characterized for their binding affinity at the MB327 binding site of nicotinic acetylcholine receptor (nAChR) from…
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Keywords:
series;
acetylcholine receptor;
nicotinic acetylcholine;
mb327 ... See more keywords
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Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.10.024
Abstract: Irreversible inhibition of the acetylcholine esterase upon intoxication with organophosphorus compounds leads to an accumulation of acetylcholine in the synaptic cleft and a subsequent desensitization of nicotinic acetylcholine receptors which may ultimately result in respiratory…
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Keywords:
acetylcholine;
nicotinic acetylcholine;
bispyridinium compound;
binding sites ... See more keywords
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Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.11.006
Abstract: Medical countermeasures for acute poisoning by organophosphorus nerve agents are generally assessed over 24h following poisoning and a single administration of treatment. At 24h, the antinicotinic bispyridinium compound MB327 (1,10-(propane-1,3-diyl)bis(4-tert-butylpyridinium)) dimethanesulfonate is as effective as…
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Keywords:
protection;
treatment;
end point;
soman ... See more keywords