Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor
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DOI: 10.1002/cmdc.201800325
Abstract: A novel series of 30 symmetric bispyridinium and related N‐heteroaromatic bisquaternary salts with a propane‐1,3‐diyl linker was synthesized and characterized for their binding affinity at the MB327 binding site of nicotinic acetylcholine receptor (nAChR) from… read more here.
Keywords: series; acetylcholine receptor; nicotinic acetylcholine; mb327 ... See more keywords
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.10.024
Abstract: Irreversible inhibition of the acetylcholine esterase upon intoxication with organophosphorus compounds leads to an accumulation of acetylcholine in the synaptic cleft and a subsequent desensitization of nicotinic acetylcholine receptors which may ultimately result in respiratory… read more here.
Keywords: acetylcholine; nicotinic acetylcholine; bispyridinium compound; binding sites ... See more keywords
Efficacy of the antinicotinic compound MB327 against soman poisoning - Importance of experimental end point.
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DOI: 10.1016/j.toxlet.2017.11.006
Abstract: Medical countermeasures for acute poisoning by organophosphorus nerve agents are generally assessed over 24h following poisoning and a single administration of treatment. At 24h, the antinicotinic bispyridinium compound MB327 (1,10-(propane-1,3-diyl)bis(4-tert-butylpyridinium)) dimethanesulfonate is as effective as… read more here.
Keywords: protection; treatment; end point; soman ... See more keywords