Optochemical Control of TET Dioxygenases Enables Kinetic Insights into the Domain-Dependent Interplay of TET1 and MBD1 while Oxidizing and Reading 5-Methylcytosine
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DOI: 10.1021/acschembio.2c00245
Abstract: Methyl-CpG binding domain (MBD) proteins and ten-eleven-translocation (TET) dioxygenases are the readers and erasers of 5-methylcytosine (5mC), the central epigenetic mark of mammalian DNA. We employ light-activatable human TET1 controlled by a genetically encoded photocaged… read more here.
Keywords: tet dioxygenases; dependent interplay; mbd1; domain ... See more keywords
MBD1-dependent recruitment of SUV39h1 induces H3K9me3-mediated transcriptional silencing of Oprm1 in dorsal root ganglia after peripheral nerve injury
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DOI: 10.1177/17448069251389416
Abstract: The downregulation of mu-opioid receptor (MOR) expression in dorsal root ganglia (DRG) following peripheral nerve injury plays a pivotal role in neuropathic pain development and contributes to the reduced efficacy of morphine analgesia. The molecular… read more here.
Keywords: transcriptional silencing; suv39h1; mbd1; injury ... See more keywords