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   Articles with "mbd2" as a keyword



Density Control over MBD2 Receptor-Coated Surfaces Provides Superselective Binding of Hypermethylated DNA

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recommendations! Published in 2022 at "ACS Applied Materials & Interfaces"

DOI: 10.1021/acsami.2c09641

Abstract: Using the biomarker hypermethylated DNA (hmDNA) for cancer detection requires a pretreatment to isolate or concentrate hmDNA from nonmethylated DNA. Affinity chromatography using a methyl binding domain-2 (MBD2) protein can be used, but the relatively… read more here.

Keywords: control mbd2; hypermethylated dna; receptor; density control ... See more keywords

Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C

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recommendations! Published in 2021 at "Oncogenesis"

DOI: 10.1038/s41389-021-00366-3

Abstract: Acute myeloid leukemia (AML) is a deadly cancer characterized by an expanded self-renewal capacity that is associated with the accumulation of immature myeloid cells. Emerging evidence shows that methyl-CpG-binding domain protein 2 (MBD2), a DNA… read more here.

Keywords: cell cycle; loss mbd2; mbd2; mll af9 ... See more keywords

Rational discovery of antimetastatic agents targeting the intrinsically disordered region of MBD2

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recommendations! Published in 2019 at "Science Advances"

DOI: 10.1126/sciadv.aav9810

Abstract: The intrinsically disordered region of MBD2 is a promising target for treating cancer metastasis. Although intrinsically disordered protein regions (IDPRs) are commonly engaged in promiscuous protein-protein interactions (PPIs), using them as drug targets is challenging… read more here.

Keywords: rational discovery; mbd2; region mbd2; intrinsically disordered ... See more keywords

MBD2 Ablation Impairs Lymphopoiesis and Impedes Progression and Maintenance of T-ALL.

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recommendations! Published in 2018 at "Cancer research"

DOI: 10.1158/0008-5472.can-17-1434

Abstract: Aberrant DNA methylation patterns in leukemia might be exploited for therapeutic targeting. In this study, we employed a genetically deficient mouse model to explore the role of the methylated DNA binding protein MBD2 in normal… read more here.

Keywords: wnt signaling; mbd2 ablation; mbd2; progression maintenance ... See more keywords

Loss of MBD2 is associated with tumor growth in small intestinal neuroendocrine tumors

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recommendations! Published in 2025 at "Endocrine Connections"

DOI: 10.1530/ec-25-0169

Abstract: Small intestinal neuroendocrine tumors (SI-NETs) represent the most frequent neoplasms of the small intestine, with loss of chromosome 18 as the most common genetic aberration. To date, no highly frequently mutated genes have been identified… read more here.

Keywords: mbd2; tumor; cell; neuroendocrine tumors ... See more keywords