The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis.
Sign Up to like & getrecommendations! Published in 2020 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2019.12.006
Abstract: BACKGROUND AND AIMS Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease that causes liver cirrhosis, leading to liver failure. Additionally, PSC is a risk factor for cholangiocarcinoma. Its mechanism is unknown, and liver transplantation… read more here.
Keywords: cell line; mboat7 rs641738; primary sclerosing; mboat7 ... See more keywords
MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04991-0
Abstract: Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C > T MBOAT7/TMC4 variant predisposes to progressive NAFLD, but the impact on hepatic carcinogenesis is unknown. In… read more here.
Keywords: hepatocellular carcinoma; hcc; cirrhotic individuals; mboat7 rs641738 ... See more keywords