Adaptive molecular evolution of MC1R gene reveals the evidence for positive diversifying selection in indigenous goat populations
Sign Up to like & getrecommendations! Published in 2017 at "Ecology and Evolution"
DOI: 10.1002/ece3.2919
Abstract: Abstract Detecting signatures of selection can provide a new insight into the mechanism of contemporary breeding and artificial selection and further reveal the causal genes associated to the phenotypic variation. However, the signatures of selection… read more here.
Keywords: positive diversifying; mc1r; selection; goat ... See more keywords
The genetic basis and enigmatic origin of melanic polymorphism in pomarine skuas (Stercorarius pomarinus)
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2017.1735
Abstract: A key outstanding issue in adaptive evolution is the relationship between the genetics of intraspecific polymorphism and interspecific evolution. Here, we show that the pale/dark ventral plumage polymorphism that occurs in both the pomarine skua… read more here.
Keywords: mc1r; pomarine skuas; pomarine; polymorphism ... See more keywords
Functional characterization of cAMP signaling of variant porcine MC1R alleles in PK15 cells.
Sign Up to like & getrecommendations! Published in 2022 at "Animal genetics"
DOI: 10.1111/age.13189
Abstract: The melanocortin 1 receptor (MC1R), encoded by the classical extension (E) coat color locus, is expressed on the surface of melanocytes and plays a critical role in switching melanin synthesis from pheomelanin (red/yellow) to eumelanin… read more here.
Keywords: mc1r alleles; variant porcine; mc1r; porcine mc1r ... See more keywords
Identification of two new recessive MC1R alleles in red-coloured Evolèner cattle and other breeds.
Sign Up to like & getrecommendations! Published in 2022 at "Animal genetics"
DOI: 10.1111/age.13206
Abstract: Sequence variations in the melanocortin-1 receptor (MC1R) gene are associated with melanism in different animal species. Six functionally relevant alleles have been described in cattle to date. In a hypothesis-free approach we performed a genome-wide… read more here.
Keywords: cattle breeds; evol ner; identification two; mc1r ... See more keywords
Dermoscopy comparative approach for early diagnosis in familial melanoma: influence of MC1R genotype
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.16679
Abstract: MC1R polymorphisms interact with CDKN2A mutations modulating melanoma risk and contribute to a less suspicious clinical and dermoscopic appearance of melanomas. Different strategies, including dermoscopic comparative approach and digital monitoring, are used for the melanoma… read more here.
Keywords: comparative approach; melanoma; diagnosis; mc1r ... See more keywords
AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-2595
Abstract: Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC-variants) are associated with impaired DNA damage repair and increased melanoma risk. MC1R signaling is critically dependent on palmitoylation, primarily mediated… read more here.
Keywords: rhc; phosphorylates zdhhc13; melanomagenesis; mc1r ... See more keywords
Abstract CT104: MC1R imaging and histology in the targeted imaging of melanoma for alpha-particle radiotherapy (TIMAR1) trial
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct104
Abstract: Purpose: Melanocortin 1 receptor (MC1R) has been shown in animal models to be a target for effective radionuclide therapy. This first-in-human clinical trial studied the safety and biodistribution of two novel MC1R-targeted imaging tracers designed… read more here.
Keywords: melanoma; targeted imaging; mc1r; trial ... See more keywords
NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1591-4
Abstract: BackgroundNeuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently, melanocortin-1 receptor (Mc1r) activation by Nle4-D-Phe7-α-MSH (NDP-MSH) was shown to play a neuroprotective role in an… read more here.
Keywords: mc1r; bbb disruption; ndp msh; neuroinflammation bbb ... See more keywords
Association of MC1R variation and plumage color diversity of Nigerian domestic pigeon (Columba livia domestica)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Advanced Veterinary and Animal Research"
DOI: 10.5455/javar.2022.i604
Abstract: Objectives: Domestic pigeons (Columba livia domestica) have diverse plumage pigmentations. Melanocortin 1 receptor (MC1R) gene variation has been correlated with color traits. The association between MC1R and plumage coloration in African domestic pigeons is yet… read more here.
Keywords: domestic pigeons; plumage; mc1r; variation ... See more keywords