An Improved Synthesis of Ionizable Lipids D‐Lin‐KC2‐DMA and D‐Lin‐MC3‐DMA
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500592
Abstract: Considerable interest exists in ionizable lipids (ILs) for the delivery of nucleic acid therapeutics. While not a component of a yet‐approved medication, lipid KC2 is especially competent for the delivery of plasmid DNA, consequently it… read more here.
Keywords: mc3; improved synthesis; ionizable lipids; synthesis ionizable ... See more keywords
Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00033
Abstract: Ionizable cationic lipids are essential for efficient in vivo delivery of RNA by lipid nanoparticles (LNPs). DLin-MC3-DMA (MC3), ALC-0315, and SM-102 are the only ionizable cationic lipids currently clinically approved for RNA therapies. ALC-0315 and… read more here.
Keywords: mc3; alc 0315; ionizable cationic; dlin mc3 ... See more keywords
Short-term Weight Trajectory of Severely Obese Individuals With and Without Pathogenic Satiety-Regulation Melanocortin 3/4 Receptor (MC3/4R) Mutations From a Multi-ethnic Asian Large Bariatric Surgery Program
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Investigative Medicine High Impact Case Reports"
DOI: 10.1177/23247096231168108
Abstract: The melanocortin (3 or 4) receptor (MC3/4R) is involved in regulating satiety and body weight. Therefore, pathogenic mutation in MC3/4R is associated with severe obesity, for which bariatric surgery is one of the treatment options.… read more here.
Keywords: mc3; surgery; melanocortin receptor; bariatric surgery ... See more keywords