Abstract 365: Targeting FGF21 inhibits tumor growth and attenuates cachexia in experimental colorectal cancer
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DOI: 10.1158/1538-7445.am2023-365
Abstract: Background: Colorectal cancer (CRC) is frequently accompanied by cachexia, an uncured multi-organ wasting syndrome, debilitating musculoskeletal health, physical function, and overall survival. Fibroblast growth factor 21 (FGF21) is a modulator of musculoskeletal health and metabolism… read more here.
Keywords: growth; fgf21; mc38; colorectal cancer ... See more keywords
Abstract 5110: Locally administered Interleukin-15 combined with cancer cell-targeted near-infrared photoimmunotherapy in a syngeneic mouse cancer model
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DOI: 10.1158/1538-7445.am2023-5110
Abstract: Near-infrared photoimmunotherapy (NIR-PIT) is a new anti-cancer treatment by NIR light-induced photochemical reactions within antibody-IRdye700DX conjugates, leading to significant immunogenic cell death. The efficacy of NIR-PIT is synergistically enhanced by combining immune activating agents including… read more here.
Keywords: cell; mc38; nir pit; tumor ... See more keywords