Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity
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DOI: 10.1172/jci.insight.132778
Abstract: MC4R mutations represent the largest monogenic cause of obesity, resulting mainly from receptor misfolding and intracellular retention by the cellular quality control system. The present study aimed at determining whether pharmacological chaperones (PCs) that restore… read more here.
Keywords: mouse models; mc4r linked; mc4r; linked obesity ... See more keywords