Evaluation of hepatic function using dynamic contrast-enhanced magnetic resonance imaging in melanocortin 4 receptor-deficient mice as a model of nonalcoholic steatohepatitis.
Sign Up to like & getrecommendations! Published in 2019 at "Magnetic resonance imaging"
DOI: 10.1016/j.mri.2018.11.013
Abstract: INTRODUCTION Melanocortin 4 receptor-deficient (MC4R-KO) mice fed a high-fat diet (HFD) develop liver pathology similar to human nonalcoholic steatohepatitis (NASH). However, although liver histology and blood biochemistry have been reported, hepatic function has not been… read more here.
Keywords: mc4r mice; mice; mice fed; rho ... See more keywords
Deficient melanocortin-4 receptor causes abnormal reproductive neuroendocrine profile in female mice.
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DOI: 10.1530/rep-16-0341
Abstract: Deletion of the melanocortin-4-receptor (Mc4r) gene in mice causes hyperphagia, followed by hyperinsulinemia, obesity and progressive infertility. Evidence shows that the number of developed corpora lutea is reduced in obese MC4R-knockout (MC4R KO) female mice,… read more here.
Keywords: mc4r mice; corpora lutea; melanocortin receptor; mice ... See more keywords