Effect of electroacupuncture on expressions of VEGF and CD31 in MCAO model rats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Acupuncture and Tuina Science"
DOI: 10.1007/s11726-017-1020-0
Abstract: ObjectiveTo investigate the effect of electroacupuncture (EA) at Ganshu (BL 18) and Shenshu (BL 23) on vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (PECAM-1)/CD31 around the cerebral infarction focus in middle… read more here.
Keywords: group; model; vegf cd31; acupoint group ... See more keywords
Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.10.024
Abstract: 12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, LOXBlock-1(LB1), in… read more here.
Keywords: fecl3 induced; tpa; distal mcao; lb1 ... See more keywords
MiR-202-5p attenuates neurological deficits and neuronal injury in MCAO model rats and OGD-induced injury in Neuro-2a cells by targeting eIF4E-mediated induction of autophagy and inhibition of Akt/GSK-3β pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2019.101497
Abstract: Ischemic stroke is a common cerebrovascular disease caused by insufficient blood supply to the brain. In recent years, studies have demonstrated that microRNAs (miRNAs) are involved in a variety of biological processes in the nervous… read more here.
Keywords: ogd induced; induced injury; n2a cells; mcao ... See more keywords
Activation of nucleotide-binding oligomerization domain-containing protein 1 by diaminopimelic acid contributes to cerebral ischemia-induced cognitive impairment
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135547
Abstract: Cerebral ischemia-reperfusion (I/R)-induced brain tissue injury is a major obstacle for acute stroke management. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is reported to play a critical role in the regulation of myocardial or hepatic I/R… read more here.
Keywords: nucleotide binding; cerebral ischemia; binding oligomerization; oligomerization domain ... See more keywords
Electroacupuncture improved depressive behaviors and synaptic plasticity of post-stroke depressed mice via inhibiting the JNK signaling pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Neurological research"
DOI: 10.1080/01616412.2025.2520017
Abstract: ABSTRACT Objectives The safety and effectiveness of electroacupuncture (EA) in treating depression have been scientifically validated. Recent evidence indicates that the c-Jun N-terminal kinase (JNK) pathway is a therapeutic target for anti-depression. This study examines… read more here.
Keywords: jnk signaling; signaling pathway; mcao; synaptic plasticity ... See more keywords
Electroacupuncture alleviates cerebral ischemia injury by regulating PI3K/AKT/NF-κB signaling in microglia of ischemic stroke rats
Sign Up to like & getrecommendations! Published in 2024 at "NeuroReport"
DOI: 10.1097/wnr.0000000000002115
Abstract: This study aimed to investigate the potential of electroacupuncture as an intervention for inducing ‘Awakening and Opening of the Brain’ in rats with stroke models induced by middle cerebral artery occlusion/reperfusion (MCAO/R). The efficacy of… read more here.
Keywords: ischemic stroke; electroacupuncture; akt signaling; mcao ... See more keywords
Distal versus Proximal Middle Cerebral Artery Occlusion: Different Mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Cerebrovascular Diseases"
DOI: 10.1159/000500947
Abstract: Background: Clinical and radiological characteristics of middle cerebral artery (MCA) infarction may differ according to the location of occlusion. Objectives: We investigated the difference between proximal and distal symptomatic MCA occlusion (MCAO) in patients with… read more here.
Keywords: proximal mcao; mca; artery; distal mcao ... See more keywords
Abstract TP395: Alzheimer's Disease model APP/PS1 mice exhibit motor deficits following 15-minute focal ischemia.
Sign Up to like & getrecommendations! Published in 2025 at "Stroke"
DOI: 10.1161/str.56.suppl_1.tp395
Abstract: Introduction: Ischemic stroke is one of the leading causes of death in the United States and is a known risk factor for Alzheimer’s Disease (AD) development. One of the characterizations of AD is the accumulation… read more here.
Keywords: mice; mcao; motor; app ps1 ... See more keywords
Lipopolysaccharide worsens the prognosis of experimental cerebral ischemia via interferon gamma-induced protein 10 recruit in the acute stage
Sign Up to like & getrecommendations! Published in 2019 at "BMC Neuroscience"
DOI: 10.1186/s12868-019-0547-z
Abstract: BackgroundInfection is an important clinical complication facing stroke-patients and triples the risk of death within 30 days post-stroke via mechanisms which are poorly understood.AimsWe tried to explore the mechanisms that inflammation caused by infections aggravated the… read more here.
Keywords: gamma induced; acute stage; interferon gamma; mcao ... See more keywords
Cathodal tDCS exerts neuroprotective effect in rat brain after acute ischemic stroke
Sign Up to like & getrecommendations! Published in 2020 at "BMC Neuroscience"
DOI: 10.1186/s12868-020-00570-8
Abstract: Background Transcranial direct current stimulation (tDCS) is a non-invasive brain modulation technique that has been proved to exert beneficial effects in the acute phase of stroke. To explore the underlying mechanism, we investigated the neuroprotective… read more here.
Keywords: tdcs; brain damage; mcao; cathodal tdcs ... See more keywords
Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1326-y
Abstract: BackgroundThe migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF),… read more here.
Keywords: treatment; interferon; peripheral immune; interferon gamma ... See more keywords