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   Articles with "mcao" as a keyword



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Effect of electroacupuncture on expressions of VEGF and CD31 in MCAO model rats

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recommendations! Published in 2017 at "Journal of Acupuncture and Tuina Science"

DOI: 10.1007/s11726-017-1020-0

Abstract: ObjectiveTo investigate the effect of electroacupuncture (EA) at Ganshu (BL 18) and Shenshu (BL 23) on vascular endothelial growth factor (VEGF) and platelet endothelial cell adhesion molecule-1 (PECAM-1)/CD31 around the cerebral infarction focus in middle… read more here.

Keywords: group; model; vegf cd31; acupoint group ... See more keywords
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Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2017.10.024

Abstract: 12/15-Lipoxygenase (12/15-LOX) contributes to the brain damage after middle cerebral artery occlusion (MCAO) in the acute phase of stroke. The aim of this study was to investigate the effects of a 12/15-LOX inhibitor, LOXBlock-1(LB1), in… read more here.

Keywords: fecl3 induced; tpa; distal mcao; lb1 ... See more keywords
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MiR-202-5p attenuates neurological deficits and neuronal injury in MCAO model rats and OGD-induced injury in Neuro-2a cells by targeting eIF4E-mediated induction of autophagy and inhibition of Akt/GSK-3β pathway.

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recommendations! Published in 2019 at "Molecular and cellular probes"

DOI: 10.1016/j.mcp.2019.101497

Abstract: Ischemic stroke is a common cerebrovascular disease caused by insufficient blood supply to the brain. In recent years, studies have demonstrated that microRNAs (miRNAs) are involved in a variety of biological processes in the nervous… read more here.

Keywords: ogd induced; induced injury; n2a cells; mcao ... See more keywords
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Activation of nucleotide-binding oligomerization domain-containing protein 1 by diaminopimelic acid contributes to cerebral ischemia-induced cognitive impairment

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recommendations! Published in 2021 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2020.135547

Abstract: Cerebral ischemia-reperfusion (I/R)-induced brain tissue injury is a major obstacle for acute stroke management. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is reported to play a critical role in the regulation of myocardial or hepatic I/R… read more here.

Keywords: nucleotide binding; cerebral ischemia; binding oligomerization; oligomerization domain ... See more keywords
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Distal versus Proximal Middle Cerebral Artery Occlusion: Different Mechanisms

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recommendations! Published in 2019 at "Cerebrovascular Diseases"

DOI: 10.1159/000500947

Abstract: Background: Clinical and radiological characteristics of middle cerebral artery (MCA) infarction may differ according to the location of occlusion. Objectives: We investigated the difference between proximal and distal symptomatic MCA occlusion (MCAO) in patients with… read more here.

Keywords: proximal mcao; mca; artery; distal mcao ... See more keywords
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Lipopolysaccharide worsens the prognosis of experimental cerebral ischemia via interferon gamma-induced protein 10 recruit in the acute stage

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recommendations! Published in 2019 at "BMC Neuroscience"

DOI: 10.1186/s12868-019-0547-z

Abstract: BackgroundInfection is an important clinical complication facing stroke-patients and triples the risk of death within 30 days post-stroke via mechanisms which are poorly understood.AimsWe tried to explore the mechanisms that inflammation caused by infections aggravated the… read more here.

Keywords: gamma induced; acute stage; interferon gamma; mcao ... See more keywords
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Cathodal tDCS exerts neuroprotective effect in rat brain after acute ischemic stroke

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recommendations! Published in 2020 at "BMC Neuroscience"

DOI: 10.1186/s12868-020-00570-8

Abstract: Background Transcranial direct current stimulation (tDCS) is a non-invasive brain modulation technique that has been proved to exert beneficial effects in the acute phase of stroke. To explore the underlying mechanism, we investigated the neuroprotective… read more here.

Keywords: tdcs; brain damage; mcao; cathodal tdcs ... See more keywords
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Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion

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recommendations! Published in 2018 at "Journal of Neuroinflammation"

DOI: 10.1186/s12974-018-1326-y

Abstract: BackgroundThe migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF),… read more here.

Keywords: treatment; interferon; peripheral immune; interferon gamma ... See more keywords
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Roles of isometric contraction training in promoting neuroprotection and angiogenesis after stroke in adult rats.

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recommendations! Published in 2022 at "Physiological research"

DOI: 10.33549/physiolres.934849

Abstract: 100 rats were randomly divided into a sham-operated group and middle cerebral artery occlusion (MCAO) modeling groups. The sham group after surgery was observed for 14 days. After MCAO, some rats received isometric contraction training… read more here.

Keywords: mcao; contraction training; isometric contraction; expression ... See more keywords
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mtDNA-STING Axis Mediates Microglial Polarization via IRF3/NF-κB Signaling After Ischemic Stroke

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.860977

Abstract: Neuroinflammation is initiated in response to ischemic stroke, and is usually characterized by microglial activation and polarization. Stimulator of interferon genes (STING) has been shown to play a critical role in anti-tumor immunity and inflammatory… read more here.

Keywords: ischemic stroke; microglial polarization; stroke; polarization via ... See more keywords
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Exercise Intervention Modulates Synaptic Plasticity by Inhibiting Excessive Microglial Activation via Exosomes

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recommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"

DOI: 10.3389/fncel.2022.953640

Abstract: Background Exosomes can activate microglia to modulate neural activity and synaptic plasticity by phagocytosis of neural spines or synapses. Our previous research found that an early 4-week exercise intervention in middle cerebral artery occlusion (MCAO)… read more here.

Keywords: group; mcao; mcao exo; exercise intervention ... See more keywords