Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF‐κB signaling and reducing oxidative stress
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30811
Abstract: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by fat accumulation and chronic inflammation in the liver. Dynein light chain of 8 kDa (LC8) was identified previously as an inhibitor of nuclear factor kappa B (NF‐κB),… read more here.
Keywords: mcd diet; dynein light; oxidative stress; mice ... See more keywords
Multiparametric ultrasound imaging for the assessment of normal versus steatotic livers
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82153-z
Abstract: Liver disease is increasing in prevalence across the globe. We present here a multiparametric ultrasound (mpUS) imaging approach for assessing nonalcoholic fatty liver disease (NALFD). This study was performed using rats (N = 21) that were fed… read more here.
Keywords: normal versus; multiparametric ultrasound; ultrasound imaging; mcd diet ... See more keywords
Hepatoprotective effect of Qushihuayu formula on non-alcoholic steatohepatitis induced by MCD diet in rat
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DOI: 10.1186/s13020-021-00434-1
Abstract: Background Non-alcoholic steatohepatitis (NASH) is an advanced form of non-alcoholic fatty liver disease (NAFLD) for which there is yet any standard pharmacotherapy. Traditional Chinese medicine formula such as Qushihuayu (QSHY) composing of multiple bioactive compounds… read more here.
Keywords: medicine; qshy formula; non alcoholic; formula ... See more keywords
Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0179099
Abstract: Non-alcoholic steatohepatitis (NASH) is a liver disease with the potential to lead to cirrhosis and hepatocellular carcinoma. Interleukin-6 (IL-6) has been implicated in the pathogenesis of NASH, with the so-called IL-6 ‘trans-signaling’ cascade being responsible… read more here.
Keywords: non alcoholic; diet induced; mcd diet; alcoholic steatohepatitis ... See more keywords
Morphological Changes in Major Salivary Glands in Mice Treated With a Choline and Methionine Deficient Diet
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DOI: 10.21873/invivo.12951
Abstract: Abstract Background/Aim: It has been shown that the methionine-choline deficient (MCD) diet induces hepatocarcinogenesis, but not in extrahepatic organs, such as the testis, and pancreas, although may increase chemical-induced carcinogenesis in the colon, mammary gland,… read more here.
Keywords: mcd diet; major salivary; changes major; salivary glands ... See more keywords
Curcumin Ameliorates Nonalcoholic Fatty Liver Disease through Inhibition of O-GlcNAcylation
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DOI: 10.3390/nu11112702
Abstract: The cause of progression to non-alcoholic fatty liver disease (NAFLD) is not fully understood. In the present study, we aimed to investigate how curcumin, a natural phytopolyphenol pigment, ameliorates NAFLD. Initially, we demonstrated that curcumin… read more here.
Keywords: fatty liver; mcd diet; glcnacylation; liver disease ... See more keywords
Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2018 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v24.i23.2468
Abstract: AIM To investigate changes in gut microbiota and metabolism during nonalcoholic steatohepatitis (NASH) development in mice fed a methionine-choline-deficient (MCD) diet. METHODS Twenty-four male C57BL/6J mice were equally divided into four groups and fed a… read more here.
Keywords: methionine choline; mcd diet; group; gut microbiota ... See more keywords