Synthesis and SARs study of novel spiro-oxindoles as potent antiproliferative agents with CDK-2 inhibitory activities.
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300185
Abstract: A series of 16 novel spirooxindole analogs 8a-p were designed and constructed via cost-effective single-step multicomponent [3+2] cycloaddition reaction of azomethine ylide (AY) generated in situ from substituted isatin (6a-d) with suitable amino acids (7a-c)… read more here.
Keywords: mcf; novel spiro; synthesis sars; sars study ... See more keywords
Fischer–Tropsch Synthesis Bifunctional Catalysts: Cobalt Supported on 3D Mesoporous Cellular Silica Foams Assembled by Using ZSM‐5 Seeds
Sign Up to like & getrecommendations! Published in 2017 at "ChemCatChem"
DOI: 10.1002/cctc.201700539
Abstract: Mesoporous cellular silica foams (MCF) have 3D pore networks in which large spherical cell pores interconnect with small window pores. This novel characteristic provides an open pore structure that favors the accessibility of reactants and… read more here.
Keywords: seed; mcf; cellular silica; catalyst ... See more keywords
Atractylodin induces oxidative stress‐mediated apoptosis and autophagy in human breast cancer MCF‐7 cells through inhibition of the P13K/Akt/mTOR pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23081
Abstract: This study aimed to determine the apoptosis and autophagy‐inducing mechanism of atractylodin in human breast cancer MCF‐7 cells. The molecular mechanism of anticancer activity of atractylodin was confirmed by assessing the levels of reactive oxygen… read more here.
Keywords: mcf; apoptosis autophagy; breast cancer; human breast ... See more keywords
Inhibition of autophagic flux by the curcumin analog EF‐24 and its antiproliferative effect on MCF‐7 cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23307
Abstract: 5‐Bis[(2‐fluorophenyl)methylene]‐4‐piperidinone (EF‐24) is a curcumin analog, which was identified for its physiochemical stability and diverse pharmacological functions. In the present study, EF‐24 was added to the breast cancer cell line MCF‐7 and its cellular effects… read more here.
Keywords: mcf; autophagic flux; curcumin analog; mcf cells ... See more keywords
ROR2 promotes the epithelial-mesenchymal transition by regulating MAPK/p38 signaling pathway in breast cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.29666
Abstract: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a tyrosine-protein kinase receptor highly implicated in the growth plate and cartilage development, which may be involved in epithelial-mesenchymal transition (EMT) in breast cancer (BC) cells. Although… read more here.
Keywords: mesenchymal transition; mapk p38; mcf; breast cancer ... See more keywords
Oleuropein inhibits migration ability through suppression of epithelial‐mesenchymal transition and synergistically enhances doxorubicin‐mediated apoptosis in MCF‐7 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27586
Abstract: Distinct metastasis is one of the main causes of breast cancer (BC)‐related mortality and epithelial‐mesenchymal transition (EMT) is a primary step in metastasis dissemination. On the other hand, doxorubicin (DOX) is an effective chemotherapeutic agent… read more here.
Keywords: mcf cells; apoptosis; mcf; migration ability ... See more keywords
Enhanced mechanical and thermal properties of polypropylene/cellulose fibers composites with modified tannic as a compatibilizer
Sign Up to like & getrecommendations! Published in 2018 at "Polymer Composites"
DOI: 10.1002/pc.24165
Abstract: A novel compatibilizer tannic grafted poly(12-hydroxy stearate) (TA-g-PHS) was synthesized using tannic and 12-hydroxystearic acid as raw materials through the esterification reaction. The compatibilizer was used to improve the compatibility between polypropylene (PP) and microcrystalline… read more here.
Keywords: composites modified; mcf; enhanced mechanical; cellulose fibers ... See more keywords
Quantitative evaluation of facial hypoplasia and airway obstruction in infants with syndromic craniosynostosis: relationship with skull base and splanchnocranium sutural pattern
Sign Up to like & getrecommendations! Published in 2018 at "Neuroradiology"
DOI: 10.1007/s00234-018-2005-5
Abstract: PurposeCraniosynostostic syndromes are due to multisuture synostoses and affect the entire craniofacial skeleton. This study analyzed the facial complex and airways to quantify the relationship between insufficient facial growth, airways obstruction, and the sutural pattern… read more here.
Keywords: sutural pattern; mcf; group; infants syndromic ... See more keywords
Estrogenic effects of phytoestrogens derived from Flemingia strobilifera in MCF-7 cells and immature rats
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-018-1027-1
Abstract: Phytoestrogen (PE) has received considerable attention due to the physiological significance of its estrogenicity. Flemingia strobilifera (FS) has been used as a folk medicine in Asia for the treatment of inflammation, cancer, and infection; however,… read more here.
Keywords: mcf cells; fse compounds; mcf; estrogenic effects ... See more keywords
Triphenylphosphonium-modified mitochondria-targeted paclitaxel nanocrystals for overcoming multidrug resistance
Sign Up to like & getrecommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2018.06.006
Abstract: Mitochondria are currently known as novel targets for treating cancer, especially for tumors displaying multidrug resistance (MDR). This present study aimed to develop a mitochondria-targeted delivery system by using triphenylphosphonium cation (TPP+)-conjugated Brij 98 as… read more here.
Keywords: targeted ptx; mitochondria targeted; mcf; mcf adr ... See more keywords
A Dual Fluorescent 3-D Multicellular Coculture of Breast Cancer MCF-7 and Fibroblast NIH-3T3 Cells for High Throughput Cancer Drug Screening
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2019.05.007
Abstract: Abstract Tumor microenvironment plays a vital role in tumor progression, metastasis and aggressiveness. The interaction between tumor and surrounding stromal cells, especially fibroblasts, is closely related to antitumor drug sensitivity. We developed a novel 3-dimensional… read more here.
Keywords: mcf; drug; coculture; cancer ... See more keywords