Abstract 2906: Functional and therapeutic significance of DNA ligase I (LIG1) depletion in triple-negative breast cancer (TNBC)
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DOI: 10.1158/1538-7445.am2025-2906
Abstract: We recently reported a proteogenomic study of TNBCs that demonstrated a correlation between chemoresistance and heterozygous LIG1 loss, a critical ligase serving DNA replication and repair (PMID: 36001024). Thus, this translational study aims to functionally… read more here.
Keywords: cancer; mcf 12a; cell; parpi ... See more keywords
Characterization of MCF-12A cell phenotype, response to estrogens, and growth in 3D
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DOI: 10.1186/s12935-018-0534-y
Abstract: BackgroundThree-dimensional cultures of mammary epithelial cells allow for biologically-relevant studies of the development of the mammary gland in rodents and humans under normal and pathological conditions, like carcinogenesis. Under these conditions, mammotropic hormones play significant… read more here.
Keywords: 12a cell; cell phenotype; mcf 12a; 12a cells ... See more keywords
Comparison of the Toxicological Effects of Pesticides in Non-Tumorigenic MCF-12A and Tumorigenic MCF-7 Human Breast Cells
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DOI: 10.3390/ijerph19084453
Abstract: Humans are exposed to residues of organophosphate and neonicotinoid pesticides, commonly used in agriculture. Children are particularly vulnerable and, among possible adverse outcomes, the increased incidence of premature mammary gland development (thelarche) has raised concern.… read more here.
Keywords: non tumorigenic; mcf; toxicological effects; tumorigenic mcf ... See more keywords
Phytochemicals from Pterocarpus angolensis DC and Their Cytotoxic Activities against Breast Cancer Cells
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DOI: 10.3390/plants13020301
Abstract: Pterocarpus anglonesis DC is an indigenous medicinal plant belonging to the Pterocarpus genus of the Fabaceae family. It is used to treat stomach problems, headaches, mouth ulcers, malaria, blackwater fever, gonorrhea, ringworm, diarrhea, heavy menstruation,… read more here.
Keywords: breast cancer; cancer; cancer cells; mcf 12a ... See more keywords