Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies
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DOI: 10.1038/s41467-024-48653-y
Abstract: Mitochondrial respiration is essential for the survival and function of T cells used in adoptive cellular therapies. However, strategies that specifically enhance mitochondrial respiration to promote T cell function remain limited. Here, we investigate methylation-controlled… read more here.
Keywords: mcj; cd8; mitochondrial respiration; efficacy ... See more keywords
The outcome of boosting mitochondrial activity in alcoholic liver disease (ALD) is organ-dependent.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000303
Abstract: OBJECTIVE Alcoholic liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one of the earliest manifestations of alcohol-induced injury, restoring mitochondrial activity remains a… read more here.
Keywords: liver; alcoholic liver; disease; mcj ... See more keywords