Mantle cell lymphoma in 2022 - A comprehensive update on molecular pathogenesis, risk stratification, clinical approach, and current and novel treatments.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of hematology"
DOI: 10.1002/ajh.26523
Abstract: The field of mantle cell lymphoma (MCL) has witnessed remarkable progress due to relentless advances in molecular pathogenesis, prognostication, and newer treatments. MCL consists of a spectrum of clinical subtypes. Rarely, atypical cyclin D1-negative MCL… read more here.
Keywords: cell lymphoma; mcl; molecular pathogenesis; mantle cell ... See more keywords
Fragment‐Based Design, Synthesis, and Biological Evaluation of 1‐Substituted‐indole‐2‐carboxylic Acids as Selective Mcl‐1 Inhibitors
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DOI: 10.1002/ardp.201600251
Abstract: Based on a known selective Mcl‐1 inhibitor, 6‐chloro‐3‐(3‐(4‐chloro‐3,5‐dimethylphenoxy)propyl)‐1H‐indole‐2‐carboxylic acid, we applied a fragment‐based approach to obtain new molecules that extended into the p1 pocket of the BH3 groove and then exhibited binding selectivity for the… read more here.
Keywords: mcl; indole carboxylic; selective mcl; fragment based ... See more keywords
EBV‐MIR‐BHRF1‐1 TARGETS P53 GENE: POTENTIAL ROLE IN EPSTEIN‐BARR VIRUS ASSOCIATED CHRONIC LYMPHOCYTIC LEUKEMIA
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.42_2631
Abstract: cell lines and paired ibrutinb resistant patients primary cells. Resistant MEC-1 cell line was cultured in RPMI 1640 without ibrutinib for 48hrs before transfection, siRNA targeting with PTBP1 mRNA and nontargeting siRNA were transfected into… read more here.
Keywords: mcl; cell line; ibrutinib; ptbp1 ... See more keywords
Mcl‐1 targeting could be an intriguing perspective to cure cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26786
Abstract: The Bcl‐2 family, which plays important roles in controlling cancer development, is divided into antiapoptotic and proapoptotic members. The change in the balance between these members governs the life and death of the cells. Mcl‐1… read more here.
Keywords: mcl; mcl targeting; targeting could; could intriguing ... See more keywords
Effect of locally applied simvastatin on clinical attachment level and alveolar bone in periodontal maintenance patients: A randomized clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Periodontology"
DOI: 10.1002/jper.21-0708
Abstract: Abstract Background The purpose of this double‐masked, randomized, controlled trial was to determine if the local application of simvastatin (SIM), combined with minimally invasive papilla reflection and root planing (PR/RP), is effective in improving clinical… read more here.
Keywords: bop; clinical attachment; attachment level; periodontal maintenance ... See more keywords
Incarceration of the medial collateral ligament in the intercondylar notch following proximal avulsion
Sign Up to like & getrecommendations! Published in 2017 at "Skeletal Radiology"
DOI: 10.1007/s00256-017-2723-5
Abstract: Intra-articular entrapment of the medial collateral ligament (MCL) is a rare but recognised complication of traumatic injury to the posteromedial corner (PMC) of the knee. Considering the MCL is the most commonly injured ligament of… read more here.
Keywords: mcl; ligament; avulsion; collateral ligament ... See more keywords
UMI-77 primes glioma cells for TRAIL-induced apoptosis by unsequestering Bim and Bak from Mcl-1
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2997-x
Abstract: Malignant glioma is the most common and aggressive form of brain tumor with poor prognosis of survival. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent but is insufficient of inducing apoptosis in… read more here.
Keywords: mcl; apoptosis; bim bak; glioma cells ... See more keywords
Inertial optimization MCL deep mine localization algorithm based on grey prediction and artificial bee colony
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DOI: 10.1007/s11276-021-02633-y
Abstract: To solve the problem that the existing Monte Carlo Localization (MCL) algorithm has long localization time and large localization error in the real-time localization of downhole personnel and mobile equipment, an inertial optimization MCL deep… read more here.
Keywords: bee colony; mcl; algorithm; deep mine ... See more keywords
Blastoid Mantle Cell Lymphoma of the Palate: Report of a Rare Aggressive Entity and Review of the Literature
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DOI: 10.1007/s12105-021-01391-9
Abstract: Mantle cell lymphoma (MCL) is a well-defined, non-Hodgkin lymphoma of B-cell origin displaying diverse morphological phenotypes and variable disease course. The World Health Organization recognizes two aggressive histopathologic variants of this type of lymphoma: pleomorphic… read more here.
Keywords: mcl; literature; mantle cell; cell ... See more keywords
JSH practical guidelines for hematological malignancies, 2018: II. Lymphoma-4. Mantle cell lymphoma (MCL)
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02784-x
Abstract: Mantle cell lymphoma is a neoplasm with the same cell surface phenotype as the B cells that compose the mantle zone of lymphatic follicles. It is an independent disease entity characterized by positive findings for… read more here.
Keywords: mcl; lymphoma; index; mantle cell ... See more keywords
Production of polyhydroxybutyrate and polyhydroxybutyrate-co-MCL copolymers from brewer’s spent grains by recombinant Escherichia coli LSBJ
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DOI: 10.1007/s13399-021-01738-w
Abstract: This study investigates the use of brewer’s spent grains (BSG), a major waste stream from the brewing process, for its potential as a carbon source for the fermentative production of polyhydroxyalkanoates (PHAs), biodegradable polyesters. The… read more here.
Keywords: mcl; production; spent grains; brewer spent ... See more keywords