Gestational exposure to environmental cadmium induces placental apoptosis and fetal growth restriction via Parkin-modulated MCL-1 degradation.
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DOI: 10.1016/j.jhazmat.2021.127268
Abstract: Heavy metal cadmium (Cd), a classical environmental pollutant, causes placental apoptosis and fetal growth restriction (FGR), whereby the mechanism remains unclear. Here, our human case-control study firstly showed that there was a positive association of… read more here.
Keywords: placental apoptosis; apoptosis; placental trophoblasts; mcl degradation ... See more keywords
Nutrient Deprivation Promotes MCL-1 Degradation in an Autophagy-Independent Manner
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DOI: 10.1134/s0006297920100119
Abstract: Abstract The antiapoptotic protein Mcl-1, which is an attractive target for cancer treatment, is degraded under nutrient deprivation conditions in different types of cancer. This process sensitizes cancer cells to chemotherapy. It has been found… read more here.
Keywords: independent manner; deprivation; mcl degradation; cancer ... See more keywords