Regulation of Human Mcl-1 by a Divergently-Expressed Antisense Transcript.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.145016
Abstract: Mcl-1 is a member of the Bcl-2 anti-apoptotic protein family with important roles in the development, lifespan and metabolism of lymphocytes, as well as oncogenesis. Mcl-1 displays the shortest half-life of all Bcl-2 family members,… read more here.
Keywords: mcl; mcl expression; regulation human; mcl1 as1 ... See more keywords
CHAMP1 (CAMP) plays a role in cell survival through regulating Mcl-1 expression.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer science"
DOI: 10.1111/cas.15018
Abstract: Anti-mitotic drugs such as vinca alkaloids and taxanes cause mitotic cell death after prolonged mitotic arrest. However, a fraction of cells escape from mitotic arrest by undergoing mitotic slippage, which is related to resistance to… read more here.
Keywords: anti mitotic; mcl expression; mitotic drugs; champ1 ... See more keywords
Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14223
Abstract: The regulation of Mcl-1 expression is necessary for the induction of cancer cell apoptosis by ABTs such as ABT-737, ABT-263 and ABT-199. However, the reduction in Mcl-1 expression is not sufficient for initiating cell death… read more here.
Keywords: abt 199; apoptosis; mcl expression; jnk activation ... See more keywords
Increased MCL-1 expression predicts poor prognosis and disease recurrence in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s194549
Abstract: Background: Altered expression of the BCL-2 family member MCL-1 has been linked to the progression and outcome of various malignancies. Recently, MCL-1 inhibitor S63845 was reported to kill MCL-1-dependent cancer cells and has potential value… read more here.
Keywords: expression; acute myeloid; leukemia; prognosis ... See more keywords
Targeting of Mcl-1 Expression by MiRNA-3614-5p Promotes Cell Apoptosis of Human Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084194
Abstract: MicroRNA (miRNA) acts as a critical regulator of growth in various human malignancies. However, the role of miRNA-3614 in the progression of human prostate cancer remains unknown. In this study, our results demonstrated that miRNA-3614-5p… read more here.
Keywords: human prostate; prostate cancer; mirna 3614; mcl expression ... See more keywords