Discovery of a Turn-On Fluorescent Probe for Myeloid Cell Leukemia-1 Protein.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b01148
Abstract: The environment-sensitive probe 2 with turn-on switch for Mcl-1 protein was developed herein. After careful evaluation, this small molecule fluorescent probe revealed a selective binding affinity with Mcl-1 protein with a Ki value of 2.6… read more here.
Keywords: protein; turn fluorescent; fluorescent probe; mcl protein ... See more keywords
Measurements of Mcl-1 protein dependencies using dimerization-specific antibodies as predictive biomarkers for BH-3 mimetic class therapies in AML.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e19505
Abstract: e19505Background: The anti-apoptotic Bcl-2 family proteins facilitate pro-survival and resistance to anti-cancer therapies. Measuring the function of these proteins has shown utility in predicting ... read more here.
Keywords: dimerization specific; measurements mcl; mcl protein; protein dependencies ... See more keywords