Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant
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DOI: 10.1128/mcb.00033-20
Abstract: Upon replication fork arrest, the replication checkpoint kinase Cds1 is stimulated to preserve genome integrity. Robust activation of Cds1 in response to hydroxyurea prevents the endonuclease Mus81 from cleaving the stalled replication fork inappropriately. However,… read more here.
Keywords: instability; replication; cds1; replication checkpoint ... See more keywords