miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114610
Abstract: Microchromosome maintenance protein 7 (MCM7), a DNA replication permitting factor, plays an essential role in initiating DNA replication. MCM7 is reported to be involved in tumor formation and progression, whereas the expression profile and molecular… read more here.
Keywords: mir 107; colorectal cancer; proliferation; crc ... See more keywords
In silico investigation of the role of vitamins in cancer therapy through inhibition of MCM7 oncoprotein
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DOI: 10.1039/d2ra03703c
Abstract: An overabundance of MCM7 protein, a component of the minichromosome maintenance complex that normally initiates DNA replication, has been reported to cause different types of cancers with aggressive malignancy. Inhibition of MCM7 may lead to… read more here.
Keywords: cancer therapy; inhibition mcm7; cancer; mcm7 ... See more keywords
MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2021.1991372
Abstract: OBJECTIVE Aberrant DNA replication is regarded as a component of cancer development. Minichromosome maintenance protein 7 (MCM7), which is critical for the initiation of DNA replication, is overexpressed in multiple malignancies. The effect of MCM7… read more here.
Keywords: pi3k akt; cancer; mcm7; cell ... See more keywords
First Report of Berkeleyomyces basicola Causing Black Root Rot on Lisianthus (Eustoma grandiflorum) in China.
Sign Up to like & getrecommendations! Published in 2021 at "Plant disease"
DOI: 10.1094/pdis-08-21-1724-pdn
Abstract: Lisianthus (Eustoma grandiflorum (Raf.) Shinn.) is an important ornamental plant ranking in the top 10 cut flowers worldwide (Xiao et al., 2018). In 2020 and 2021, black root rot was found as a major disease… read more here.
Keywords: mcm7; black root; root rot; plant ... See more keywords
PRMT5 promotes colorectal cancer growth by interaction with MCM7
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DOI: 10.1111/jcmm.16436
Abstract: Protein arginine methyltransferase 5 (PRMT5) is a type of methyltransferase enzyme that can catalyse arginine methylation of histones and non‐histone proteins. Accumulating evidence indicates that PRMT5 promotes cancer development and progression. However, its function in… read more here.
Keywords: prmt5 promotes; colorectal cancer; prmt5; crc ... See more keywords
Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2020-107518
Abstract: Background Minichromosomal maintenance (MCM) complex components 2, 4, 5 and 6 have been linked to human disease with phenotypes including microcephaly and intellectual disability. The MCM complex has DNA helicase activity and is thereby important… read more here.
Keywords: microcephaly intellectual; intellectual disability; autosomal recessive; recessive primary ... See more keywords
MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas.
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DOI: 10.1530/eje-20-1086
Abstract: OBJECTIVE Current markers predicting tumour progression of pituitary adenomas after surgery are insufficient. Our objective was to investigate if minichromosome maintenance protein 7 (MCM7) expression predicts tumour progression in non-functioning pituitary adenomas (NFPAs). METHODS In… read more here.
Keywords: expression; pituitary adenomas; mcm7; progression ... See more keywords
Computational Screening of Natural Compounds for Identification of Potential Anti-Cancer Agents Targeting MCM7 Protein
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DOI: 10.3390/molecules26195878
Abstract: Minichromosome maintenance complex component 7 (MCM7) is involved in replicative licensing and the synthesis of DNA, and its overexpression is a fascinating biomarker for various cancer types. There is currently no effective agent that can… read more here.
Keywords: screening natural; computational screening; cancer; mcm7 protein ... See more keywords