MCM8 is regulated by EGFR signaling and promotes the growth of glioma stem cells through its interaction with DNA-replication-initiating factors
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DOI: 10.1038/s41388-021-01888-1
Abstract: Mini-chromosome maintenance (MCM) proteins are critical components of DNA-replication-licensing factors. MCM8 is an MCM protein that exhibits oncogenic functions in several human malignancies. However, the role of MCM8 in glioblastomas (GBMs) has remained unclear. In… read more here.
Keywords: mcm8; regulated egfr; dna replication; expression ... See more keywords
Knockdown of MCM8 inhibits development and progression of bladder cancer in vitro and in vivo
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DOI: 10.1186/s12935-021-01948-2
Abstract: Background Bladder cancer is a frequently diagnosed urinary system tumor, whose mortality remains rising. Minichromosome maintenance eight homologous recombination repair factor (MCM8), a newly discovered MCM family member, has been shown to be required for… read more here.
Keywords: bladder cancer; mcm8; vitro; cancer ... See more keywords