5-LO-derived LTB4 plays a key role in MCP-1 expression in HMGB1-exposed VSMCs via a BLTR1 signaling axis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90636-2
Abstract: Monocyte chemoattractant protein-1 (MCP-1) plays an important role in initiating vascular inflammation; however, its cellular source in the injured vasculatures is unclear. Given the importance of high mobility group box 1 (HMGB1) in tissue injury,… read more here.
Keywords: hmgb1; bltr1; expression; role ... See more keywords
Interleukin-6 trans-signaling regulates monocyte chemoattractant protein-1 production in immune-mediated necrotizing myopathy.
Sign Up to like & getrecommendations! Published in 2024 at "Rheumatology"
DOI: 10.1093/rheumatology/keae118
Abstract: OBJECTIVE Immune-mediated necrotizing myopathy (IMNM) is pathologically characterized by diffuse myofiber necrosis and regeneration, myophagocytosis, and a sparse inflammatory infiltrate. The monocyte chemoattractant protein-1 (MCP-1) is a key chemokine that regulates monocyte/macrophage infiltration into injured… read more here.
Keywords: mediated necrotizing; mcp expression; immune mediated; monocyte chemoattractant ... See more keywords
Pb Induces MCP-1 in the Choroid Plexus
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11020308
Abstract: Simple Summary Our data in this study show that oral Pb exposure can induce MCP-1 expression along with monocyte and macrophage infiltration in the choroid plexus. Both NF-κB and p38 MAPK pathways modulate Pb-induced MCP-1… read more here.
Keywords: mcp expression; expression; macrophage infiltration; exposure ... See more keywords