Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genes
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32503
Abstract: Viruses can inhibit host autophagy through multiple mechanisms, and evasion of autophagy plays an important role in immune suppression and viral oncogenesis. Merkel cell polyomavirus (MCPyV) T‐antigens are expressed and involved in the pathogenesis of… read more here.
Keywords: cell polyomavirus; autophagy; merkel cell; mcpyv ... See more keywords
Evaluation of Merkel cell polyomavirus in non-small cell lung cancer and adjacent normal cells.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.04.033
Abstract: Several risk factors have been linked to lung cancer (LC). Nevertheless, a viral etiology has been mentioned for a subset of patients developing LC. The aim of this study was to evaluate the effect of… read more here.
Keywords: mcpyv dna; mcpyv; cell; lung cancer ... See more keywords
Immunological evidence of an early seroconversion to oncogenic Merkel cell polyomavirus in healthy children and young adults
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13601
Abstract: Oncogenic Merkel cell polyomavirus (MCPyV) provokes a widespread and asymptomatic infection in humans. Herein, sera from healthy children and young adults (HC, n = 344) aged 0–20 years old were evaluated for anti‐MCPyV immunoglobulin G (IgG)… read more here.
Keywords: oncogenic merkel; merkel cell; mcpyv; cell polyomavirus ... See more keywords
Merkel Cell Polyomavirus Infection of Animal Dermal Fibroblasts
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01610-17
Abstract: ABSTRACT Merkel cell polyomavirus (MCPyV) is the first polyomavirus to be associated with human cancer. Mechanistic studies attempting to fully elucidate MCPyV's oncogenic mechanisms have been hampered by the lack of animal models for MCPyV… read more here.
Keywords: infection; animal; merkel cell; mcpyv ... See more keywords
The Ubiquitin-Specific Protease Usp7, a Novel Merkel Cell Polyomavirus Large T-Antigen Interaction Partner, Modulates Viral DNA Replication
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.01638-19
Abstract: MCPyV is the only human polyomavirus that is associated with cancer; the majority of Merkel cell cancers have a viral etiology. While much emphasis was placed on investigations to understand the transformation process by MCPyV… read more here.
Keywords: viral dna; merkel cell; dna; replication ... See more keywords
Molecular Mechanisms of Merkel Cell Polyomavirus Transformation and Replication.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of virology"
DOI: 10.1146/annurev-virology-011720-121757
Abstract: Viral infection underlies a significant share of the global cancer burden. Merkel cell polyomavirus (MCPyV) is the newest member of the human oncogenic virus family. Its discovery over a decade ago marked the beginning of… read more here.
Keywords: merkel cell; mcpyv; virology; cell polyomavirus ... See more keywords
The small tumor antigen of Merkel cell polyomavirus accomplishes cellular transformation by uniquely localizing to the nucleus despite the absence of a known nuclear localization signal
Sign Up to like & getrecommendations! Published in 2024 at "Virology Journal"
DOI: 10.1186/s12985-024-02395-x
Abstract: Background Merkel Cell Carcinoma (MCC) is an aggressive skin cancer that is three times deadlier than melanoma. In 2008, it was found that 80% of MCC cases are caused by the genomic integration of a… read more here.
Keywords: polyomavirus; mcpyv; tumor; merkel cell ... See more keywords
No detectable truncating mutations in large T antigen (LT-Ag) sequence of Merkel cell polyomavirus (MCPyV) DNA obtained from porocarcinomas
Sign Up to like & getrecommendations! Published in 2024 at "Infectious Agents and Cancer"
DOI: 10.1186/s13027-024-00568-5
Abstract: Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma (MCC). In tumor cells the MCPyV large T antigen (LT-Ag) is frequently found truncated and this is considered a major tumor-specific signature. The role of… read more here.
Keywords: truncating mutations; mcpyv; merkel cell; dna ... See more keywords
Expression of Notch 3 and Jagged 1 Is Associated With Merkel Cell Polyomavirus Status and Prognosis in Merkel Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "AntiCancer Research"
DOI: 10.21873/anticanres.13114
Abstract: Background/Aim: Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin cancer and most MCCs are related to infection with Merkel cell polyomavirus (MCPyV). Notch signaling modulates cell fate in various tissues including the skin… read more here.
Keywords: status prognosis; merkel cell; mcpyv; expression ... See more keywords
Serum Antibodies Against the Oncogenic Merkel Cell Polyomavirus Detected by an Innovative Immunological Assay With Mimotopes in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.676627
Abstract: Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, has been detected in Merkel cell carcinoma (MCC) and in normal tissues. Since MCPyV infection occurs in both MCC-affected patients and healthy subjects (HS), innovative immunoassays… read more here.
Keywords: merkel cell; mcpyv; assay; cell polyomavirus ... See more keywords
Detection of Merkel Cell Polyomavirus in Seborrheic Keratosis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.02648
Abstract: Seborrheic keratosis (SK) is the most common benign cutaneous neoplasm. A subset shows increased p16 expression. Since SK shares several features with verruca vulgaris, e.g., increased p16 expression, human papillomaviruses (HPV) have been suggested as… read more here.
Keywords: detection; expression; seborrheic keratosis; p16 expression ... See more keywords