Lack of experimental evidence to support mcr-1-positive Escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2017.04.013
Abstract: In this study, we assessed the selective effect of colistin administered orally to healthy weaned piglets harbouring an intestinal mcr-1-positive Escherichia coli strain. Maximum recommended dose and a higher dose often used in European pig… read more here.
Keywords: coli strain; escherichia coli; mcr positive; positive escherichia ... See more keywords
Identification of mcr-1-positive multidrug-resistant Escherichia coli isolates from clinical samples in Shanghai, China.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2022.02.008
Abstract: OBJECTIVES Since the gene encoding mobilized colistin resistance (mcr-1) was first reported in China in 2015, it has been reported in various Enterobacteriaceae worldwide. Escherichia coli, one of the main pathogens causing diarrhea, is the… read more here.
Keywords: mcr; mcr positive; resistance; escherichia coli ... See more keywords
Imported food and feed as contributors to the introduction of plasmid‐mediated colistin‐resistant Enterobacteriaceae to a ‘low prevalence’ country
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx161
Abstract: Sir, In the last year, it has become evident that the plasmid-located colistin resistance gene mcr-1 has a worldwide distribution. Colistin is widely used in veterinary medicine, particularly in pigs and poultry, and the selection… read more here.
Keywords: colistin; mcr positive; plasmid mediated; resistance ... See more keywords
Identification of a novel adjuvant loperamide that enhances the antibacterial activity of colistin against MCR-1-positive pathogens in vitro/vivo.
Sign Up to like & getrecommendations! Published in 2023 at "Letters in applied microbiology"
DOI: 10.1093/lambio/ovad025
Abstract: Severe infection with MDR Enterobacterales caused by the plasmid-induced colistin resistance gene MCR-1 is a serious public health challenge. In this case, it is necessary and pressing to find a treatment to overcome antibiotic resistance.… read more here.
Keywords: loperamide; mcr positive; colistin; colistin mcr ... See more keywords
Multicentre evaluation of a selective isolation protocol for detection of mcr‐positive E. coli and Salmonella spp. in food‐producing animals and meat
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DOI: 10.1111/lam.13717
Abstract: This study was conducted to evaluate the performance of a screening protocol to detect and isolate mcr‐positive Escherichia coli and Salmonella spp. from animal caecal content and meat samples. We used a multicentre approach involving… read more here.
Keywords: food; coli salmonella; salmonella spp; mcr positive ... See more keywords
Quantitative Pharmacodynamic Characterization of Resistance versus Heteroresistance of Colistin in E. coli Using a Semimechanistic Modeling of Killing Curves
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DOI: 10.1128/aac.00793-22
Abstract: Heteroresistance corresponds to the presence, in a bacterial isolate, of an initial small subpopulation of bacteria characterized by a significant reduction in their sensitivity to a given antibiotic. Mechanisms of heteroresistance versus resistance are poorly… read more here.
Keywords: mcr; mcr positive; colistin; resistance ... See more keywords
The Prevalence of Plasmid-Mediated Colistin Resistance Gene mcr-1 and Different Transferability and Fitness of mcr-1-Bearing IncX4 Plasmids in Escherichia coli from Pigeons
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03639-22
Abstract: The emergence of plasmid-mediated colistin resistance gene mcr-1 incurs great concerns. Since the close proximity of pigeons with humans, it is significant to understand the prevalence and molecular characterization of mcr-1-positive isolates in pigeons, to… read more here.
Keywords: mcr; prevalence; mcr positive; incx4 plasmids ... See more keywords
Prevalence and Genomic Characteristics of mcr-Positive Escherichia coli Strains Isolated from Humans, Pigs, and Foods in China
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DOI: 10.1128/spectrum.04569-22
Abstract: The spread of polymyxin-resistant Enterobacteriaceae poses a significant threat to public health and challenges the therapeutic options for treating infections on a global level. In this study, mcr-1-bearing ST10 E. coli was isolated from pigs,… read more here.
Keywords: public health; mcr; prevalence; mcr positive ... See more keywords
Prevalence and molecular characteristics of mcr-1 gene in Salmonella typhimurium in a tertiary hospital of Zhejiang Province
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DOI: 10.2147/idr.s190269
Abstract: Objectives mcr-1 gene has been widely reported in the world. This study aimed to analyze the prevalence and molecular characteristics of mcr-1 gene in Salmonella typhimurium from Quzhou People's Hospital. Materials and methods A total… read more here.
Keywords: mcr positive; prevalence molecular; typhimurium; mcr gene ... See more keywords
Evaluation of Commercial Products for Colistin and Polymyxin B Susceptibility Testing for mcr-Positive and Negative Escherichia coli and Klebsiella pneumoniae in China
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DOI: 10.2147/idr.s400772
Abstract: Purpose To evaluate the performance of five widespread commercial products for colistin and polymyxin B susceptibility testing in China for mcr-positive and -negative Escherichia coli and Klebsiella pneumoniae. Methods A total of 132 E. coli… read more here.
Keywords: mcr positive; colistin polymyxin; polymyxin susceptibility; polymyxin ... See more keywords
Colistin Resistance and Molecular Characterization of the Genomes of mcr-1-Positive Escherichia coli Clinical Isolates
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.854534
Abstract: Research on resistance against polymyxins induced by the mcr-1 gene is gaining interest. In this study, using agar dilution method, polymerase chain reaction, and comparative genomic analysis, we investigated the colistin resistance mechanism of clinical… read more here.
Keywords: mcr positive; mic levels; resistance; colistin resistance ... See more keywords