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   Articles with "mct induced" as a keyword



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Liquiritigenin and liquiritin alleviated MCT‐induced HSOS by activating Nrf2 antioxidative defense system

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recommendations! Published in 2018 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2018.06.014

Abstract: ABSTRACT Hepatic sinusoidal obstruction syndrome (HSOS) is a serious and life‐threatening liver disease. Liquiritigenin (LG) and liquiritin (LQ) are natural flavonoids distributed in Glycyrrhizae Radix et Rhizoma (Gan‐cao). This study aims to investigate the protective… read more here.

Keywords: mct; mct induced; liquiritigenin liquiritin; nrf2 antioxidative ... See more keywords
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Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury.

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recommendations! Published in 2019 at "Toxicology"

DOI: 10.1016/j.tox.2019.152307

Abstract: Hepatic sinusoidal obstruction syndrome (HSOS) is a life-threatening liver disease caused by the damage to liver sinusoidal endothelial cells (LSECs). Liquiritigenin and liquiritin are two main compounds in Glycyrrhizae Radix et Rhizoma (Gan-cao). Our previous… read more here.

Keywords: liquiritin alleviated; mct induced; liquiritigenin liquiritin; liquiritin ... See more keywords
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Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension.

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recommendations! Published in 2021 at "Clinical science"

DOI: 10.1042/cs20210612

Abstract: Pulmonary hypertension (PH) is a life-threatening disease characterized by vascular remodeling. Exploring new therapy target is urgent. The purpose of this study is to investigate whether and how spliced x-box binding protein 1 (xbp1s), a… read more here.

Keywords: protein; pulmonary hypertension; xbp1s; mct induced ... See more keywords
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Protective effects of Dapagliflozin on the vulnerability of ventricular arrhythmia in rats with pulmonary artery hypertension induced by monocrotaline

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2021.2017652

Abstract: ABSTRACT Monocrotaline (MCT)-induced pulmonary artery hypertension (PAH) has been reported to cause right heart failure (RHF). Moreover, Right heart diseases have been determined to cause ventricular arrhythmia (VA). So we can conclude that MCT-induced PAH… read more here.

Keywords: mct; pulmonary artery; ventricular arrhythmia; pah ... See more keywords
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The protective role of EP300 in monocrotaline-induced pulmonary hypertension

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recommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"

DOI: 10.3389/fcvm.2023.1037217

Abstract: Background Pulmonary hypertension (PH) is a lethal disease characterized by pulmonary vascular remodeling, which is mediated by the abnormal proliferation/migration of pulmonary arterial smooth muscle cells (PASMCs). Recent reports suggest the involvement of histone acetylation… read more here.

Keywords: mct induced; pulmonary hypertension; ep300; ep300 promoter ... See more keywords
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Role of Endothelin-1 in Right Atrial Arrhythmogenesis in Rabbits with Monocrotaline-Induced Pulmonary Arterial Hypertension

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms231910993

Abstract: Atrial arrhythmias are considered prominent phenomena in pulmonary arterial hypertension (PAH) resulting from atrial electrical and structural remodeling. Endothelin (ET)-1 levels correlate with PAH severity and are associated with atrial remodeling and arrhythmia. In this… read more here.

Keywords: induced pah; mct induced; pulmonary arterial; arterial hypertension ... See more keywords
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Cannabidiol Improves Antioxidant Capacity and Reduces Inflammation in the Lungs of Rats with Monocrotaline-Induced Pulmonary Hypertension

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27103327

Abstract: Cannabidiol (CBD) is a plant-derived compound with antioxidant and anti-inflammatory properties. Pulmonary hypertension (PH) is still an incurable disease. CBD has been suggested to ameliorate monocrotaline (MCT)-induced PH, including reduction in right ventricular systolic pressure… read more here.

Keywords: pulmonary hypertension; antioxidant capacity; cbd; mct induced ... See more keywords
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Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-κB pathways

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recommendations! Published in 2022 at "International Journal of Medical Sciences"

DOI: 10.7150/ijms.69289

Abstract: Pulmonary arterial hypertension (PAH) characterized by pulmonary vascular remodeling is a lethal disease. Paeoniflorin (PF) is a monoterpene glycoside with numerous beneficial functions, such as vasodilation, anti-inflammation and immunomodulation. This study aims to investigate the… read more here.

Keywords: arterial hypertension; mapk pathways; pulmonary arterial; mct induced ... See more keywords