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1
Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27829
Abstract: Subacute ruminal acidosis (SARA) is characterized by the depression of ruminal pH and an increase in the concentrations of short‐chain fatty acids (SCFAs) and lipopolysaccharide (LPS) in the rumen of cows. The onset of SARA…
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Keywords:
mct1;
ruminal acidosis;
rumen cows;
subacute ruminal ... See more keywords
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Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23415
Abstract: Diallyl trisulfide (DATS) is a promising small molecule phytochemical that exhibits in vitro and in vivo activity in multiple preclinical solid tumor models including breast cancer, but the underlying mechanism is not fully understood. We…
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Keywords:
inhibition;
breast;
mct1;
breast cancer ... See more keywords
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Published in 2022 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-022-00805-4
Abstract: Tumor cells often exhibit the Warburg effect, wherein, they preferentially undergo glycolysis over oxidative phosphorylation for energy production. Monocarboxylate transporter 1 (MCT1) and 4 (MCT4) are critical symporters mediating lactate efflux and preventing intracellular acidification…
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Keywords:
tcl;
expression;
mct1 mct4;
monocarboxylate transporter ... See more keywords
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Published in 2018 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-018-9763-y
Abstract: Monocarboxylate transporter 1 (MCT1) has been reported to be correlated wtih decreased survival and advanced stage of progression in a series of human tumor cells and primary cancers. Specifically, MCT1 has been documented to be…
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Keywords:
invasion;
pi3k akt;
invasion migration;
mct1 ... See more keywords
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Published in 2019 at "Cellular Oncology"
DOI: 10.1007/s13402-019-00426-2
Abstract: PurposeIncreased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role…
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Keywords:
lymphoma;
metabolism related;
non hodgkin;
mct1 ... See more keywords
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1
Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.053
Abstract: MCT1 transporters play a crucial role in the symbiotic relationship between humans and their colonic microbiome by facilitating the transport of bacteria-derived short chain fatty acids. Expression of colonic MCT1 transporters, localized in surface epithelial…
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Keywords:
mct1 transporters;
mct1;
cell;
colon adenocarcinoma ... See more keywords
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Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01612
Abstract: The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer; however, the MCT1 modulator landscape is underexplored with only roughly 100 reported compounds. To expand the knowledge…
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Keywords:
transporter mct1;
transporter;
mct1 slc16a1;
monocarboxylate transporter ... See more keywords
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1
Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.3115
Abstract: 3115 Background: Tumours rely on lactate transporters (MCT1-4) to maintain glycolytic flux and avoid intracellular acidification. In haematological tumours the MCT1 transporter acts as a lactate and pyruvate exporter. AZD3965 is a potent and specific…
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Keywords:
dlbcl;
fdg pet;
mct1;
lymphoma ... See more keywords
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1
Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18215
Abstract: Tumors frequently display a glycolytic phenotype with increased flux through glycolysis and concomitant synthesis of lactate. To maintain glycolytic flux and prevent intracellular acidification, tumors efflux lactate via lactate transporters (MCT1-4). Inhibitors of lactate transport…
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Keywords:
pharmacology;
mct1;
burkitt lymphoma;
inhibitor mct1 ... See more keywords
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Published in 2020 at "Cancers"
DOI: 10.3390/cancers12030581
Abstract: Metabolite exchange between stromal and tumor cells or among tumor cells themselves accompanies metabolic reprogramming in cancer including pancreatic adenocarcinoma (PDAC). Some tumor cells import and utilize lactate for oxidative energy production (reverse Warburg-metabolism) and…
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Keywords:
monocarboxylate transporter;
reverse warburg;
pdac;
lactate ... See more keywords