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1
Published in 2021 at "Glia"
DOI: 10.1002/glia.24014
Abstract: Inactivating mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) causes a rare and debilitating form of X‐linked psychomotor disability known as Allan Herndon Dudley syndrome (AHDS). One of the most prominent pathophysiological…
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Keywords:
mct8;
across brain;
oligodendrocyte progenitor;
maturation ... See more keywords
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2
Published in 2022 at "Bone"
DOI: 10.1016/j.bone.2022.116375
Abstract: Thyroid hormones are critical regulators of bone metabolism. Their cellular import is guided through transporter proteins, including the monocarboxylate transporter 8 (MCT8). Conditional Mct8 knockout in osteoblast and osteoclast precursors leads to trabecular bone gain…
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Keywords:
bone;
mct8;
trabecular bone;
transporter ... See more keywords
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1
Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67594-2
Abstract: Thyroid hormone (TH) has long been believed to play a minor role in male reproduction. However, evidences from experimental model of thyrotoxicosis or hypothyroidism suggests its role in spermatogenesis. Cellular action of TH requires membrane…
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Keywords:
spermatogenesis;
mct8;
knockout rats;
slc16a2 ... See more keywords
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2
Published in 2023 at "Thyroid"
DOI: 10.1089/thy.2022.0612
Abstract: Background: Monocarboxylate transporter 8 (MCT8) deficiency is a rare X-linked disease where patients exhibit peripheral hyperthyroidism and cerebral hypothyroidism, which results in severe neurological impairments. These brain defects arise from a lack of thyroid hormones…
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Keywords:
sob am2;
brain;
mct8 dio2;
mct8 deficient ... See more keywords
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1
Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052464
Abstract: Thyroid hormones (THs; T3 and T4) enter cells using specific transporters and regulate development and metabolism. Mutation in the TH transporter monocarboxylate transporter 8 (MCT8, SLC16A2) is associated with brain hypothyroidism and neurological impairment. We…
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Keywords:
mct8 mutant;
system mct8;
genetic neurological;
visual system ... See more keywords
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1
Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043452
Abstract: Background Patients with inactive thyroid hormone (TH) transporter MCT8 display intellectual disability due to an insufficient TH transport and action in the CNS. As a therapeutic strategy, application of Triac (3, 5, 3’-triiodothyroacetic acid) and…
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Keywords:
ditpa;
thyroid hormone;
dko mice;
mice ... See more keywords