Articles with "mct8" as a keyword



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Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane

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Published in 2021 at "Glia"

DOI: 10.1002/glia.24014

Abstract: Inactivating mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) causes a rare and debilitating form of X‐linked psychomotor disability known as Allan Herndon Dudley syndrome (AHDS). One of the most prominent pathophysiological… read more here.

Keywords: mct8; across brain; oligodendrocyte progenitor; maturation ... See more keywords
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Bone cell-specific deletion of thyroid hormone transporter Mct8 distinctly regulates bone volume in young versus adult male mice.

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Published in 2022 at "Bone"

DOI: 10.1016/j.bone.2022.116375

Abstract: Thyroid hormones are critical regulators of bone metabolism. Their cellular import is guided through transporter proteins, including the monocarboxylate transporter 8 (MCT8). Conditional Mct8 knockout in osteoblast and osteoclast precursors leads to trabecular bone gain… read more here.

Keywords: bone; mct8; trabecular bone; transporter ... See more keywords
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CRISPR/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat

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Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-67594-2

Abstract: Thyroid hormone (TH) has long been believed to play a minor role in male reproduction. However, evidences from experimental model of thyrotoxicosis or hypothyroidism suggests its role in spermatogenesis. Cellular action of TH requires membrane… read more here.

Keywords: spermatogenesis; mct8; knockout rats; slc16a2 ... See more keywords
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Maternal Administration of the CNS-Selective Sobetirome Prodrug Sob-AM2 Exerts Thyromimetic Effects in Murine MCT8-Deficient Fetuses

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Published in 2023 at "Thyroid"

DOI: 10.1089/thy.2022.0612

Abstract: Background: Monocarboxylate transporter 8 (MCT8) deficiency is a rare X-linked disease where patients exhibit peripheral hyperthyroidism and cerebral hypothyroidism, which results in severe neurological impairments. These brain defects arise from a lack of thyroid hormones… read more here.

Keywords: sob am2; brain; mct8 dio2; mct8 deficient ... See more keywords
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Genetic and Neurological Deficiencies in the Visual System of mct8 Mutant Zebrafish

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Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23052464

Abstract: Thyroid hormones (THs; T3 and T4) enter cells using specific transporters and regulate development and metabolism. Mutation in the TH transporter monocarboxylate transporter 8 (MCT8, SLC16A2) is associated with brain hypothyroidism and neurological impairment. We… read more here.

Keywords: mct8 mutant; system mct8; genetic neurological; visual system ... See more keywords
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Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice

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Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24043452

Abstract: Background Patients with inactive thyroid hormone (TH) transporter MCT8 display intellectual disability due to an insufficient TH transport and action in the CNS. As a therapeutic strategy, application of Triac (3, 5, 3’-triiodothyroacetic acid) and… read more here.

Keywords: ditpa; thyroid hormone; dko mice; mice ... See more keywords