Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13371
Abstract: Mitochondrial calcium homeostasis plays critical roles in cell survival and aerobic metabolism in eukaryotes. The calcium uniporter is a highly selective calcium ion channel consisting of several subunits. Mitochondrial calcium uniporter (MCU) and essential MCU… read more here.
Keywords: mcu; calcium uniporter; mcu emre; emre ... See more keywords
MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202203869
Abstract: Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains obscure. Mitochondrial calcium uniporter (MCU) is a key regulator for mitochondrial and… read more here.
Keywords: mcu; cadmium; mitophagy; hepatotoxicity ... See more keywords
Cardioprotection of post-ischemic moderate ROS against ischemia/reperfusion via STAT3-induced the inhibition of MCU opening
Sign Up to like & getrecommendations! Published in 2019 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-019-0747-9
Abstract: Enhanced reactive oxygen species (ROS) at the beginning of reperfusion activated signal transducer and activator of transcription 3 (STAT3) in intermittent hypobaric hypoxia (IHH)-afforded cardioprotection against ischemia/reperfusion (I/R). However, its mechanism remains largely unknown. This… read more here.
Keywords: h2o2poc; mcu; post ischemic; moderate h2o2poc ... See more keywords
Dependency of well-contact density on MCUs in 65-nm bulk CMOS SRAM
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DOI: 10.1007/s11432-017-9549-8
Abstract: Dear editor, In custom static random access memory (SRAM) cell, radiation-induced single bit upsets (SBUs) are considered as the main cause of soft error [1]. Advanced technologies and scaling down of feature sizes have made… read more here.
Keywords: mcu; well contact; density; sram ... See more keywords
Neuronal mitochondrial calcium uniporter deficiency exacerbates axonal injury and suppresses remyelination in mice subjected to experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113430
Abstract: High-capacity mitochondrial calcium (Ca2+) uptake by the mitochondrial Ca2+ uniporter (MCU) is strategically positioned to support the survival and remyelination of axons in multiple sclerosis (MS) by undocking mitochondria, buffering Ca2+ and elevating adenosine triphosphate… read more here.
Keywords: remyelination; mcu; eae thy1; mitochondrial calcium ... See more keywords
Suppression of ventricular arrhythmia by mitochondrial calcium uptake via mitochondrial calcium uniporter in the ischemic heart failure mice
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3699
Abstract: In heart failure (HF), diastolic calcium (Ca) leak from sarcoplasmic reticulum (SR) via ryanodine receptor (RyR) causes delayed after depolarization (DAD), leading ventricular arrhythmias (VAs). Recent study reported that Ca uptake into mitochondria via mitochondrial… read more here.
Keywords: heart; mcu; mitochondrial calcium; mice ... See more keywords
Toward Non-CPU Activity in Low-Power MCU-Based Measurement Systems
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Transactions on Instrumentation and Measurement"
DOI: 10.1109/tim.2019.2953374
Abstract: This article evaluates the benefits of having peripheral-triggered peripherals in a microcontroller unit (MCU) intended for low-power sensor applications. In such an architecture, the functionality is moved from the central processing unit (CPU) to the… read more here.
Keywords: toward non; mcu; cpu; low power ... See more keywords
Circulating mitochondrial genes detect acute cardiac allograft rejection: Role of the mitochondrial calcium uniporter complex
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Transplantation"
DOI: 10.1111/ajt.16387
Abstract: Acute rejection after heart transplantation increases the risk of chronic dysfunction. Disturbances in mitochondrial function may play a contributory role, however, the relationship between histological signs of rejection in the human transplanted heart and expression… read more here.
Keywords: allograft rejection; mitochondrial genes; circulating mitochondrial; mcu ... See more keywords
Cryo-EM structure of a mitochondrial calcium uniporter
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DOI: 10.1126/science.aar4056
Abstract: A channel for calcium Maintaining the correct balance of calcium concentrations between the cytosol and the mitochondria is essential for cellular physiology. A calcium-selective channel called the mitochondrial calcium uniporter (MCU) mediates calcium entry into… read more here.
Keywords: calcium uniporter; mcu; physiology; mitochondrial calcium ... See more keywords
Role of a novel MCU variant in Ca2+ handling in human platelets
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733260
Abstract: Introduction: Discovery of the molecular identity of the mitochondrial Ca2+ (mtCa2+) uniporter complex (mtCUC) provides rapid progress in characterizing mtCa2+ handling and its roles in regulating cellular functions. MCU, a pore-forming subunit of mtCUC, which… read more here.
Keywords: mcu; cell; human platelets; mcu variant ... See more keywords
Abstract 16592: Excessive MCU-Mediated Mitochondrial Calcium Uptake During Chronic Stress Impairs Cardiac Contractility
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.16592
Abstract: Calcium (Ca 2+ ) uptake into the mitochondrial matrix occurs via the mitochondrial Ca 2+ uniporter channel (mtCU) and tunes mitochondrial metabolism to meet acute changes in cellular ATP demand. However, the role of mtCU-dependent… read more here.
Keywords: uptake; mcu mice; mcu; calcium uptake ... See more keywords