Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia–reperfusion injury
Sign Up to like & getrecommendations! Published in 2021 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-021-00905-4
Abstract: Current evidence indicates that coronary microcirculation is a key target for protecting against cardiac ischemia–reperfusion (I/R) injury. Mitochondrial calcium uniporter (MCU) complex activation and mitochondrial calcium ([Ca 2+ ] m ) overload are underlying mechanisms… read more here.
Keywords: mcu complex; ischemia; reperfusion injury; injury ... See more keywords
Targeting the mitochondrial Ca2+ uniporter complex in cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13946
Abstract: Cardiovascular diseases (CVDs), the leading cause of death worldwide, share in common mitochondrial dysfunction, in specific a dysregulation of Ca2+ uptake dynamics through the mitochondrial Ca2+ uniporter (MCU) complex. In particular, Ca2+ uptake regulates the… read more here.
Keywords: mitochondrial ca2; mcu complex; ca2 uniporter; ca2 ... See more keywords
MCUB Hearts Mitochondria in Sickness, Less in Health.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation"
DOI: 10.1161/circulationaha.119.043440
Abstract: The second messenger Ca 2+ and the key metabolic organelle mitochondria are at the core of cardiac excitation-coupling. In the cardiac muscle, Ca2+ acts as a signaling molecule that governs gene expression, cardiac contraction, and… read more here.
Keywords: mcu complex; mcu; mcub; ca2 ... See more keywords
Modulation of the mitochondrial Ca2+ uniporter complex subunit expression by different shear stress patterns in vascular endothelial cells
Sign Up to like & getrecommendations! Published in 2023 at "Physiological Reports"
DOI: 10.14814/phy2.15588
Abstract: Mitochondrial calcium (mCa2+) uptake occurs via the Mitochondrial Ca2+ Uniporter (MCU) complex and plays a critical role in mitochondrial dynamics, mitophagy, and apoptosis. MCU complex activity is in part modulated by the expression of its… read more here.
Keywords: mcu; mcu complex; flow; expression ... See more keywords