L6H9 attenuates LPS‐induced acute lung injury in rats through targeting MD2
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21607
Abstract: Acute lung injury (ALI) is a clinical syndrome characterized by respiratory failure and acute inflammatory response. Myeloid differentiation protein 2 (MD2) has been reported to play a pivotal role in the recognition of LPS and… read more here.
Keywords: md2; lps induced; acute lung; attenuates lps ... See more keywords
Celastrol reverses palmitic acid (PA)‐caused TLR4‐MD2 activation‐dependent insulin resistance via disrupting MD2‐related cellular binding to PA
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26547
Abstract: Elevated plasma statured fatty acids (FFAs) cause TLR4/MD2 activation‐dependent inflammation and insulin tolerance, which account for the occurrence and development of obesity. It has been confirmed that statured palmitic acid (PA) (the most abundant FFA)… read more here.
Keywords: md2; insulin; celastrol; md2 activation ... See more keywords
Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.08.036
Abstract: Myeloid differentiation 2 (MD2) is essential to the recognition of lipopolysaccharide (LPS) and the subsequent mediation of toll-like receptor 4 (TLR4)-dependent acute inflammatory disorders including sepsis and acute lung injury. Inhibitors targeting MD2 may provide… read more here.
Keywords: md2; sepsis acute; anti inflammatory; lung injury ... See more keywords
Myeloid Differentiation Factor 2 in the Heart: Bench to bedside evidence for potential clinical benefits?
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105239
Abstract: Cardiac inflammation has been involved in many pathological processes in the heart including cardiac hypertrophy, fibrosis, adverse remodeling, and dysfunction. Myeloid differentiation factor 2 (MD2) is a key mediating protein that has been shown to… read more here.
Keywords: md2; differentiation factor; myeloid differentiation; heart ... See more keywords
MD2 Inhibits Choroidal Neovascularization via Antagonizing TLR4/MD2 Mediated Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Current Eye Research"
DOI: 10.1080/02713683.2022.2164780
Abstract: Abstract Purpose To explore the pathological mechanism of Toll-like receptor 4 (TLR4) mediating neovascular age-related macular degeneration (nAMD) and the potential role of the TLR4 coreceptor myeloid differentiation protein 2 (MD2). Methods In the study,… read more here.
Keywords: md2; l2h17; signaling pathway; tlr4 md2 ... See more keywords
Inhibition of MD2‐dependent inflammation attenuates the progression of non‐alcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13395
Abstract: Non‐alcoholic fatty liver disease (NAFLD) can progress to the more serious non‐alcoholic steatohepatitis (NASH), characterized by inflammatory injury and fibrosis. The pathogenic basis of NAFLD progressing to NASH is currently unknown, but growing evidence suggests… read more here.
Keywords: md2; alcoholic fatty; fatty liver; non alcoholic ... See more keywords
An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abb6716
Abstract: Tat-CIRP perturbed the function of MD2 and provided robust neuroprotection in cells, rodents, and gyrencephalic nonhuman primates. A peptide for two strokes Ischemic stroke and hemorrhagic stroke require different therapies. Unfortunately, the time required to… read more here.
Keywords: tat cirp; hemorrhagic stroke; tat; md2 ... See more keywords
Acertannin attenuates LPS-induced inflammation by interrupting the binding of LPS to the TLR4/MD2 complex and activating Nrf2-mediated HO-1 activation.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.2139/ssrn.4181157
Abstract: Acertannin (ACTN) is a polyphenol known for its powerful anticancer and antioxidant effects. However, its anti-inflammatory effects have not been investigated at the molecular levels. Therefore, to evaluate anti-inflammatory effects of ACTN and its signaling… read more here.
Keywords: md2; md2 complex; actn; tlr4 md2 ... See more keywords
Hydroxysafflor yellow A ameliorates Toll-like receptor 4-mediated septic cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug delivery"
DOI: 10.2174/1567201819666220413130254
Abstract: BACKGROUND Sepsis is a life-threatening condition caused by bacterially-induced systemic inflammation that can result in septic cardiomyopathy. Bacterial lipopolysaccharide (LPS) stimulates the Toll-like receptor 4 (TLR4, Tlr4)-induced inflammatory response and intracellular reactive oxygen species (ROS)… read more here.
Keywords: md2; hsya; toll like; septic cardiomyopathy ... See more keywords
High frequency callus induction and proliferation of MD2 pineapple (Ananas comosus)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Food Science"
DOI: 10.26656/fr.2017.4(s5).016
Abstract: Ananas comosus var. MD2 is currently the most preferred pineapple variety in the international market due to its pleasant aroma and high Brix acidity ratio. In vitro approaches such as callus culture is promising in… read more here.
Keywords: md2; frequency callus; md2 pineapple; callus induction ... See more keywords
Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.929222
Abstract: Toll-like receptor 4 (TLR4) is a pattern-recognition receptor (PRR) that regulates the activation of immune cells, which is a target for treating inflammation. In this study, Cannabidivarin (CBDV), an active component of Cannabis, was identified… read more here.
Keywords: md2; tlr4; cannabidivarin alleviates; tlr4 receptor ... See more keywords