Abstract 5719: Identification of EIK1004 (IMP1707), a CNS-penetrant, potent, and selective PARP1 inhibitor poised for testing in patients with HRD mutant tumors
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DOI: 10.1158/1538-7445.am2025-5719
Abstract: Nonselective poly(ADP-ribose) polymerase (PARP) inhibitors have proven to be effective in patients whose tumors harbor mutations in DNA repair proteins, although their efficacy is hampered by dose reductions and suspensions due to on-target toxicity resulting… read more here.
Keywords: brain; mda 436; parp1; cns penetrant ... See more keywords
Prometastatic Potential of Non-Functionalized Multiwalled Carbon Nanotubes in the MDA-MB-436 Breast Cancer Cell Line Model
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DOI: 10.3390/ijms26062777
Abstract: Multiwalled carbon nanotubes (MWCNTs) are used in many areas of industry and medicine. However, there is evidence suggesting profibrogenic action of MWCNTs, probably via the epithelial–mesenchymal transition mechanism (EMT). The aim of this study was… read more here.
Keywords: breast cancer; mda 436; multiwalled carbon; cell ... See more keywords