Annonaceous Acetogenin Mimic AA005 Inhibits the Growth of TNBC MDA‐MB‐468 Cells by Altering Cell Energy Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200250
Abstract: Triple‐negative breast cancer (TNBC) is a serious health issue for women worldwide and there is still no suitable treatment option. AA005, a structurally simplified mimic of natural Annonaceous acetogenins, presents outstanding properties with impressive cytotoxicity… read more here.
Keywords: cell; 468 cells; growth; energy ... See more keywords
Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: involvement of GADD45α, integrin-α5, -β5, -β1, and autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Drug delivery and translational research"
DOI: 10.1007/s13346-022-01137-2
Abstract: To date, promising therapy for triple negative breast cancer (TNBC) remains a serious concern clinically because of poor prognosis, resistance, and recurrence. Herein, anti-cancer potential of synthetic cannabidiol (CBD; Purisys, GA; GMP grade) was explored… read more here.
Keywords: integrin; tnbc; tnbc cells; treatment ... See more keywords
Observation of π-hole interactions in the solid state structures of three new copper(II) complexes with a tetradentate N4 donor Schiff base: Exploration of their cytotoxicity against MDA-MB 468 cells
Sign Up to like & getrecommendations! Published in 2017 at "Polyhedron"
DOI: 10.1016/j.poly.2016.11.012
Abstract: Abstract A new mononuclear copper(II) complex, [CuL(ClO4)2]·CH3CN (1) has been synthesized from a symmetrical tetradentate di-Schiff base, N,N′-bis(1-pyridin-2-yl-ethylidene)-2,2-dimethylpropane-1,3-diamine (L) and characterized by X-ray crystallography. Reactions of 1 separately with ammonium thiocyanate and sodium azide yielded… read more here.
Keywords: 468 cells; copper; base; observation hole ... See more keywords
In vitro and computational investigation of antioxidant and anticancer properties of Streptomyces coeruleofuscus SCJ extract on MDA-MB-468 triple-negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-76200-8
Abstract: This study aimed to explore the antioxidant potential of the ethyl acetate extract of Streptomyces coeruleofuscus SCJ strain, along with its inhibitory effects on the triple-negative human breast carcinoma cell line (MDA-MB-468). The ethyl acetate… read more here.
Keywords: streptomyces coeruleofuscus; mda 468; acid; extract ... See more keywords
Mitochondria-targeted half-sandwich iridium(iii)-Cp*-arylimidazophenanthroline complexes as antiproliferative and bioimaging agents against triple negative breast cancer cells MDA-MB-468
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra01036d
Abstract: To reduce the side effects of marketed cancer drugs against triple negative breast cancer cells we have reported mitochondria targeting half-sandwich iridium(iii)-Cp*-arylimidazophenanthroline complexes for MDA-MB-468 cell therapy and diagnosis. Out of five Ir(iii) complexes (IrL1–IrL5),… read more here.
Keywords: triple negative; iii; mda 468; breast cancer ... See more keywords
Green synthesis of silver nanoparticles having specific anticancer activity against MDA-MB 468 carcinoma cells
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Natural Sciences: Nanoscience and Nanotechnology"
DOI: 10.1088/2043-6262/abffc8
Abstract: In this work formation of silver nanoparticles using pomegranate fruit (Punica granatum) extract and its bio applications were studied. Gradual appearance of a peak at 422 nm during the reduction of AgNO3 by the fruit… read more here.
Keywords: mda 468; silver nanoparticles; anticancer activity; microscopy ... See more keywords
Anti-breast cancer activity of 7-α-hydroxyfrullanolide triggered G2/M arrest and apoptotic induction of triple negative breast cancer cell line, revealed by proteomics
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz413.043
Abstract: Abstract Background Breast cancer (BCa) affects women’s health worldwide. BCa subtype could be classified by presenting of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. Knowing of BCa subtype would be benefit… read more here.
Keywords: breast cancer; cancer cell; cancer; cell ... See more keywords
Purified Cucurbitacin D Leads to Alterations of Apoptotic and Autophagic Genes Expression in MDA-MB-468 and MCF-7 Human Breast Cancer Cells.
Sign Up to like & getrecommendations! Published in 2025 at "Asia-Pacific journal of clinical oncology"
DOI: 10.1111/ajco.70009
Abstract: AIM The use of plant-derived drugs in cancer therapy is widely considered in the treatment of different malignancies including breast cancer. Cucurbitacin D (CuD) is able to induce apoptosis in cancerous cells through different signaling… read more here.
Keywords: cancer; breast cancer; cancer cells; mda 468 ... See more keywords
Telmisartan anti‐cancer activities mechanism through targeting N‐cadherin by mimicking ADH‐1 function
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17259
Abstract: This study aimed to investigate if Telmisartan as a novel N‐cadherin antagonist, can overcome cell migration of cancer cells. We investigated the mechanism and influence of Docetaxel and Telmisartan (as an analogous to ADH‐1, which… read more here.
Keywords: cell; mda 468; cadherin; migration ... See more keywords
L-arginine dependence of breast cancer – molecular subtypes matter.
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cancer"
DOI: 10.1186/s12885-025-13908-4
Abstract: L-arginine limits proliferation in highly proliferative tissues. It is a substrate for nitric oxide synthases, arginases; its methylation by protein-L-arginine methyltransferases (PRMTs) leads to asymmetric (ADMA) and symmetric dimethylarginine (SDMA). We measured L-arginine and its… read more here.
Keywords: arginine; cancer; breast cancer; mcf ... See more keywords
β-Caryophyllene Counteracts Chemoresistance Induced by Cigarette Smoke in Triple-Negative Breast Cancer MDA-MB-468 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10092257
Abstract: Exposure to cigarette smoke (CS) has been associated with an increased risk of fatal breast cancers and recurrence, along with chemoresistance and chemotherapy impairment. This strengthens the interest in chemopreventive agents to be exploited both… read more here.
Keywords: cigarette smoke; cell; 468 cells; breast cancer ... See more keywords