Strategies for bringing stem cell-derived dopamine neurons to the clinic-The NYSTEM trial.
Sign Up to like & getrecommendations! Published in 2017 at "Progress in brain research"
DOI: 10.1016/bs.pbr.2017.02.008
Abstract: Over the last 10 years, there has been significant progress in defining culture conditions to derive bona fide human midbrain dopamine (mDA) neurons from human embryonic stem cells or from human-induced pluripotent stem cells, two… read more here.
Keywords: stem cells; mda neurons; stem cell; strategies bringing ... See more keywords
A Knockin Reporter Allows Purification and Characterization of mDA Neurons from Heterogeneous Populations.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.023
Abstract: Generation of midbrain dopaminergic (mDA) neurons from human pluripotent stem cells provides a platform for inquiry into basic and translational studies of Parkinson's disease (PD). However, heterogeneity in differentiation in vitro makes it difficult to identify… read more here.
Keywords: reporter; mda; mda neurons; purification ... See more keywords
Dopamine neuron loss by selective deletion of autophagy-related gene 5 is not exacerbated by MPTP toxicity in midbrain
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.11.037
Abstract: Parkinson's disease (PD) is a progressive neurological disease, one of the pathological characteristics is a gradual loss of midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta (SNpc). In animals, PD-like symptoms can be… read more here.
Keywords: related gene; mda neurons; autophagy related; deletion autophagy ... See more keywords