Dermatopulmonary Syndrome Associated With Anti-MDA5 Antibodies After Allogeneic Hematopoietic Stem Cell Transplantation
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2016.3976
Abstract: Importance Chronic graft-vs-host-disease (cGVHD) after allogeneic stem cell transplantation (AHSCT) may resemble autoimmune diseases. Anti-MDA5 (melanoma differentiation–associated gene 5) dermatopulmonary syndrome is a subset of dermatomyositis defined by specific clinical features and detection of anti-MDA5-antibodies… read more here.
Keywords: clinical features; anti mda5; cell transplantation; mda5 antibodies ... See more keywords
Hospitalization and Continuity of Care in Anti-MDA5 Dermatomyositis.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2024.0403
Abstract: This cohort study describes the clinical features, patient characteristics, and treatment of anti-melanoma differentiation–associated gene 5 (MDA5) dermatomyositis. read more here.
Keywords: mda5; mda5 dermatomyositis; hospitalization continuity; care anti ... See more keywords
Serum YKL-40 level is associated with severity of interstitial lung disease and poor prognosis in dermatomyositis with anti-MDA5 antibody
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Rheumatology"
DOI: 10.1007/s10067-019-04457-w
Abstract: ObjectiveWe aimed to investigate the clinical value of checking serum chitinase-3-like-1 protein (YKL-40) levels in anti-MDA5 antibody-positive dermatomyositis (anti-MDA5+DM) patients.MethodsOne hundred and five consecutive anti-MDA5+DM patients and 44 healthy controls were enrolled in this study.… read more here.
Keywords: anti mda5; serum ykl; interstitial lung; mda5 patients ... See more keywords
Role of MDA5 in regulating CXCL10 expression induced by TLR3 signaling in human rheumatoid fibroblast-like synoviocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-020-06069-z
Abstract: C-X-C motif chemokine 10 (CXCL10) is an inflammatory chemokine and a key molecule in the pathogenesis of rheumatoid arthritis (RA). Melanoma differentiation-associated gene 5 (MDA5) is an RNA helicase that plays a role in innate… read more here.
Keywords: cxcl10 expression; regulating cxcl10; role mda5; expression ... See more keywords
ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly
Sign Up to like & getrecommendations! Published in 2025 at "Cell Research"
DOI: 10.1038/s41422-025-01183-8
Abstract: MDA5 is a RIG-I-like receptor (RLR) that recognizes viral double-stranded RNA (dsRNA) to initiate the innate immune response. Its activation requires filament formation along the dsRNA, which triggers the oligomerization of N-terminal caspase activation and… read more here.
Keywords: mda5; immune homeostasis; one dimensional; filament assembly ... See more keywords
MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-27062-5
Abstract: Our innate immune responses to viral RNA are vital defenses. Long cytosolic double-stranded RNA (dsRNA) is recognized by MDA5. The ATPase activity of MDA5 contributes to its dsRNA binding selectivity. Mutations that reduce RNA selectivity… read more here.
Keywords: variant m854k; rna; atp dependent; disease ... See more keywords
MDA5 attenuate autophagy in chicken embryo fibroblasts infected with IBDV.
Sign Up to like & getrecommendations! Published in 2021 at "British poultry science"
DOI: 10.1080/00071668.2021.1969643
Abstract: The role of melanoma differentiation-associated protein 5 (MDA5) in infectious bursal disease virus (IBDV)-induced autophagy was studied in chicken embryos.Chicken embryo fibroblasts (CEF) were used as the research model and small interfering RNA (siRNA), western… read more here.
Keywords: chicken embryo; autophagy; embryo fibroblasts; ibdv ... See more keywords
Evaluation and validation of the prognostic value of anti-MDA5 IgG subclasses in dermatomyositis-associated interstitial lung disease.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac229
Abstract: OBJECTIVE To investigate the association between the anti-melanoma differentiation associated gene 5 (MDA5) IgG subclasses and prognosis of patients with dermatomyositis (DM)-associated interstitial lung disease (ILD). METHODS This retrospective study included 122 Anti-MDA5 positive DM-ILD… read more here.
Keywords: mda5 igg1; anti mda5; mda5; igg ... See more keywords
MDA5 expression is associated with TGF-β-induced fibrosis: potential mechanism of interstitial lung disease in anti-MDA5 dermatomyositis.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac234
Abstract: OBJECTIVES This study aimed to investigate the high-resolution computed tomography (HRCT) characteristics of anti-melanoma differentiation-associated gene 5 (MDA5) antibody positive dermatomyositis-associated interstitial lung disease (anti-MDA5 DM-ILD), and to clarify the underlying mechanisms of the clinical phenomenon.… read more here.
Keywords: anti mda5; mda5 ild; expression; lung ... See more keywords
P043 Pneumomediastinum and novel involvement of vocal cord in a case of anti-MDA5 antibody-positive clinically amyopathic dermatomyositis
Sign Up to like & getrecommendations! Published in 2025 at "Rheumatology"
DOI: 10.1093/rheumatology/keaf142.085
Abstract: Idiopathic inflammatory myopathies (IIMs) are a rare group of autoimmune diseases characterized by a heterogeneous clinical spectrum of muscle inflammation, rashes, arthritis, other systemic features, and characteristic evidence of autoantibodies. Anti-melanoma differentiation-associated gene 5 (MDA5)… read more here.
Keywords: mda5; vocal cord; dermatomyositis; clinically amyopathic ... See more keywords
Recurrence of anti-MDA5 antibody-positive clinically amyopathic dermatomyositis after long-term remission
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000011024
Abstract: Rationale: Among all dermatomyositis (DM) patients, antimelanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) positive patients have significantly poor short-term mortality, whereas they experience less relapses over the long term after the remission. We report the… read more here.
Keywords: long term; term remission; anti mda5; mda5 ... See more keywords