Dermatopulmonary Syndrome Associated With Anti-MDA5 Antibodies After Allogeneic Hematopoietic Stem Cell Transplantation
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2016.3976
Abstract: Importance Chronic graft-vs-host-disease (cGVHD) after allogeneic stem cell transplantation (AHSCT) may resemble autoimmune diseases. Anti-MDA5 (melanoma differentiation–associated gene 5) dermatopulmonary syndrome is a subset of dermatomyositis defined by specific clinical features and detection of anti-MDA5-antibodies… read more here.
Keywords: clinical features; anti mda5; cell transplantation; mda5 antibodies ... See more keywords
Serum YKL-40 level is associated with severity of interstitial lung disease and poor prognosis in dermatomyositis with anti-MDA5 antibody
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Rheumatology"
DOI: 10.1007/s10067-019-04457-w
Abstract: ObjectiveWe aimed to investigate the clinical value of checking serum chitinase-3-like-1 protein (YKL-40) levels in anti-MDA5 antibody-positive dermatomyositis (anti-MDA5+DM) patients.MethodsOne hundred and five consecutive anti-MDA5+DM patients and 44 healthy controls were enrolled in this study.… read more here.
Keywords: anti mda5; serum ykl; interstitial lung; mda5 patients ... See more keywords
Role of MDA5 in regulating CXCL10 expression induced by TLR3 signaling in human rheumatoid fibroblast-like synoviocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-020-06069-z
Abstract: C-X-C motif chemokine 10 (CXCL10) is an inflammatory chemokine and a key molecule in the pathogenesis of rheumatoid arthritis (RA). Melanoma differentiation-associated gene 5 (MDA5) is an RNA helicase that plays a role in innate… read more here.
Keywords: cxcl10 expression; regulating cxcl10; role mda5; expression ... See more keywords
MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-27062-5
Abstract: Our innate immune responses to viral RNA are vital defenses. Long cytosolic double-stranded RNA (dsRNA) is recognized by MDA5. The ATPase activity of MDA5 contributes to its dsRNA binding selectivity. Mutations that reduce RNA selectivity… read more here.
Keywords: variant m854k; rna; atp dependent; disease ... See more keywords
MDA5 attenuate autophagy in chicken embryo fibroblasts infected with IBDV.
Sign Up to like & getrecommendations! Published in 2021 at "British poultry science"
DOI: 10.1080/00071668.2021.1969643
Abstract: The role of melanoma differentiation-associated protein 5 (MDA5) in infectious bursal disease virus (IBDV)-induced autophagy was studied in chicken embryos.Chicken embryo fibroblasts (CEF) were used as the research model and small interfering RNA (siRNA), western… read more here.
Keywords: chicken embryo; autophagy; embryo fibroblasts; ibdv ... See more keywords
Evaluation and validation of the prognostic value of anti-MDA5 IgG subclasses in dermatomyositis-associated interstitial lung disease.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac229
Abstract: OBJECTIVE To investigate the association between the anti-melanoma differentiation associated gene 5 (MDA5) IgG subclasses and prognosis of patients with dermatomyositis (DM)-associated interstitial lung disease (ILD). METHODS This retrospective study included 122 Anti-MDA5 positive DM-ILD… read more here.
Keywords: mda5 igg1; anti mda5; mda5; igg ... See more keywords
MDA5 expression is associated with TGF-β-induced fibrosis: potential mechanism of interstitial lung disease in anti-MDA5 dermatomyositis.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac234
Abstract: OBJECTIVES This study aimed to investigate the high-resolution computed tomography (HRCT) characteristics of anti-melanoma differentiation-associated gene 5 (MDA5) antibody positive dermatomyositis-associated interstitial lung disease (anti-MDA5 DM-ILD), and to clarify the underlying mechanisms of the clinical phenomenon.… read more here.
Keywords: anti mda5; mda5 ild; expression; lung ... See more keywords
Recurrence of anti-MDA5 antibody-positive clinically amyopathic dermatomyositis after long-term remission
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000011024
Abstract: Rationale: Among all dermatomyositis (DM) patients, antimelanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) positive patients have significantly poor short-term mortality, whereas they experience less relapses over the long term after the remission. We report the… read more here.
Keywords: long term; term remission; anti mda5; mda5 ... See more keywords
Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01375-22
Abstract: PPRV infection induces cellular autophagy; however, the intracellular responses and signaling mechanisms that occur upon PPRV infection are obscure, and whether innate immune responses are linked with autophagy to regulate viral replication is largely unknown.… read more here.
Keywords: dna; infection; pprv infection; innate immune ... See more keywords
LGP2 Promotes Type I Interferon Production To Inhibit PRRSV Infection via Enhancing MDA5-Mediated Signaling
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.01843-22
Abstract: LGP2, a member of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), shows higher-affinity binding to RNA and work synergism with RIG-I or MDA5. However, LGP2 has divergent responses to different viruses, which remains controversial in… read more here.
Keywords: prrsv infection; infection; lgp2; interferon ... See more keywords
SAT0475 Anti-mda5 (+) clinically amyopathic dermatomyositis-associated rapidly progressive interstitial lung disease: role of hemoperfusion with polymyxin
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.2594
Abstract: Background Patients with clinically amyopathyc dermatomyositis (CADM) with MDA5 positive autoantibodies may develop a severe pulmonary syndrome with rapidly progressive interstitial lung disease (RP-ILD) with a bad prognosis and high mortality. Objectives To analyse the… read more here.
Keywords: mda5; anti mda5; rapidly progressive; group ... See more keywords