Bat Employs a Conserved MDA5 Gene to Trigger Antiviral Innate Immune Responses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.904481
Abstract: Bats are important hosts for various zoonotic viral diseases. However, they rarely show signs of disease infection with such viruses. As the first line for virus control, the innate immune system of bats attracted our… read more here.
Keywords: mda5 gene; virus; innate immune; antiviral innate ... See more keywords
Repeated MDA5 Gene Loss in Birds: An Evolutionary Perspective
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13112131
Abstract: Two key cytosolic receptors belonging to the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family sense the viral RNA-derived danger signals: RIG-I and melanoma differentiation-associated protein 5 (MDA5). Their activation establishes an antiviral state by… read more here.
Keywords: loss; mda5 gene; loss birds; gene ... See more keywords