ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability
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DOI: 10.1038/s41467-017-01051-z
Abstract: MDC1 plays a critical role in the DNA damage response (DDR) by interacting directly with several factors including γ-H2AX. However, the mechanism by which MDC1 is recruited to damaged sites remains elusive. Here, we show… read more here.
Keywords: mdc1; dna damage; damage response;
MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
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DOI: 10.1038/s41467-019-12929-5
Abstract: Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to promote… read more here.
Keywords: dna damage; pst repeat; h2ax; mdc1 ... See more keywords
MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites
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DOI: 10.1038/s41598-018-29239-3
Abstract: Chromatin dynamics mediated by post-translational modifications play a crucial role in cellular response to genotoxic stress for the maintenance of genome integrity. MDC1 is a pivotal chromatin adaptor in DNA damage response (DDR) and its… read more here.
Keywords: ehmt1 ehmt2; dna damage; methylation; accumulation ... See more keywords
Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
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DOI: 10.1080/19396368.2024.2325699
Abstract: Abstract MDC1 (Mediator of DNA damage Checkpoint protein 1) functions to facilitate the localization of numerous DNA damage response (DDR) components to DNA double-strand break sites. MDC1 is an integral component in preserving genomic stability… read more here.
Keywords: mdc1; prediction deleterious; p194r; medicine ... See more keywords
Abstract 4198: Unraveling the molecular interactions between DDR and autophagy in response to oxidative stress
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DOI: 10.1158/1538-7445.am2025-4198
Abstract: The DNA damage response (DDR) is essential for maintaining genomic integrity by detecting and repairing DNA damage. In conjunction with autophagy, DDR functions as a critical protective mechanism under oxidative stress, mitigating the risk of… read more here.
Keywords: ddr autophagy; mdc1; stress; oxidative stress ... See more keywords
A Novel Targeted Therapy System for Cervical Cancer: Co-Delivery System of Antisense LncRNA of MDC1 and Oxaliplatin Magnetic Thermosensitive Cationic Liposome Drug Carrier
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DOI: 10.2147/ijn.s258316
Abstract: Background This study was aimed to prepare a novel magnetic thermosensitive cationic liposome drug carrier for the codelivery of Oxaliplatin (OXA) and antisense lncRNA of MDC1 (MDC1-AS) to Cervical cancer cells and evaluate the efficiency… read more here.
Keywords: mdc1; system; cervical cancer; drug carrier ... See more keywords