Importance of OCT2 and MATE1 for the Cimetidine-Metformin Interaction: Insights from Investigations of Polarized Transport in Single- And Double-Transfected MDCK Cells with a Focus on Perpetrator Disposition.
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DOI: 10.1021/acs.molpharmaceut.8b00416
Abstract: Cimetidine decreases the renal clearance of metformin by inhibition of renal tubular cation transport, and the underlying molecular mechanisms are still not fully understood. We investigated polarized metformin transport without and with the addition of… read more here.
Keywords: mdck oct2; metformin; transport; cimetidine ... See more keywords
Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO)
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DOI: 10.1038/s41598-018-25139-8
Abstract: Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO uptake into renal proximal tubular cells. Here we investigated the potential role of multidrug… read more here.
Keywords: mdck oct2; multidrug toxin; trimethylamine oxide; oxide tmao ... See more keywords