The Genetic Architecture of Major Depressive Disorder in Han Chinese Women
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2016.3578
Abstract: Importance Despite the moderate, well-demonstrated heritability of major depressive disorder (MDD), there has been limited success in identifying replicable genetic risk loci, suggesting a complex genetic architecture. Research is needed to quantify the relative contribution… read more here.
Keywords: risk; etiology; mdd; genetic architecture ... See more keywords
Risk of Posttraumatic Stress Disorder and Major Depression in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2018.4288
Abstract: Importance Traumatic brain injury (TBI) has been associated with adverse mental health outcomes, such as posttraumatic stress disorder (PTSD) and major depressive disorder (MDD), but little is known about factors that modify risk for these… read more here.
Keywords: risk; stress disorder; mdd; posttraumatic stress ... See more keywords
Community-Level Social Support Infrastructure and Adult Onset of Major Depressive Disorder in a South Asian Postconflict Setting.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2021.4052
Abstract: Importance Individual-level social support protects against major depressive disorder (MDD) among adults exposed to trauma. Little is known about the consequences of community-level interventions in the general population. Objective To determine the potential consequences of… read more here.
Keywords: level social; social support; population; infrastructure ... See more keywords
Evaluation of Prefrontal γ-Aminobutyric Acid and Glutamate Levels in Individuals With Major Depressive Disorder Using Proton Magnetic Resonance Spectroscopy.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.3384
Abstract: Importance Major depressive disorder (MDD) is one of the most prevalent illnesses worldwide. Perturbations of the major inhibitory and excitatory neurotransmitters, γ-aminobutyric acid (GABA) and glutamate (Glu), respectively, as well as Glx (Glu or glutamine… read more here.
Keywords: past mdd; glu; spectroscopy; healthy controls ... See more keywords
Large‐scale dynamic causal modeling of major depressive disorder based on resting‐state functional magnetic resonance imaging
Sign Up to like & getrecommendations! Published in 2020 at "Human Brain Mapping"
DOI: 10.1002/hbm.24845
Abstract: Major depressive disorder (MDD) is a serious mental illness characterized by dysfunctional connectivity among distributed brain regions. Previous connectome studies based on functional magnetic resonance imaging (fMRI) have focused primarily on undirected functional connectivity and… read more here.
Keywords: depressive disorder; network; mdd; major depressive ... See more keywords
Altered intersubject functional variability of brain white‐matter in major depressive disorder and its association with gene expression profiles
Sign Up to like & getrecommendations! Published in 2024 at "Human Brain Mapping"
DOI: 10.1002/hbm.26670
Abstract: Major depressive disorder (MDD) is a clinically heterogeneous disorder. Its mechanism is still unknown. Although the altered intersubject variability in functional connectivity (IVFC) within gray‐matter has been reported in MDD, the alterations to IVFC within… read more here.
Keywords: expression profiles; mdd; brain; gene expression ... See more keywords
Predicting Antidepressant Treatment Response From Cortical Structure on MRI: A Mega‐Analysis From the ENIGMA‐MDD Working Group
Sign Up to like & getrecommendations! Published in 2025 at "Human Brain Mapping"
DOI: 10.1002/hbm.70053
Abstract: Accurately predicting individual antidepressant treatment response could expedite the lengthy trial‐and‐error process of finding an effective treatment for major depressive disorder (MDD). We tested and compared machine learning‐based methods that predict individual‐level pharmacotherapeutic treatment response… read more here.
Keywords: treatment; mdd; treatment response; response ... See more keywords
Neural Correlates of Peripheral Inflammation in Major Depressive Disorder and Their Transcriptomic Architecture, Neurochemical Basis, and Behavioral Relevance
Sign Up to like & getrecommendations! Published in 2025 at "Human Brain Mapping"
DOI: 10.1002/hbm.70371
Abstract: The role of inflammation in the neuropathology of major depressive disorder (MDD) is evident. However, the neural correlates of peripheral inflammation in MDD and their transcriptomic architecture, neurochemical basis, and behavioral relevance have not been… read more here.
Keywords: mdd; depressive disorder; major depressive; matter ... See more keywords
Aberrant Dynamic Network Connectivity Changes in Comorbid Depression and Overweight/Obesity: Insights From the Triple Network Model
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.70001
Abstract: The interaction between major depressive disorder (MDD) and overweight/obesity has received considerable attention owing to its widespread occurrence and the intricate biopsychological implications involved. Despite extensive research, the neural mechanisms underlying these comorbid conditions, particularly… read more here.
Keywords: network connectivity; mdd; overweight obesity; network ... See more keywords
Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder
Sign Up to like & getrecommendations! Published in 2020 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-020-01128-9
Abstract: Little is known about the pathophysiology of memory deficits in patients with major depressive disorder (MDD) treated with modified electroconvulsive therapy (MECT). This study examined the profiles of cytokines, the memory function, and their association… read more here.
Keywords: mdd patients; depressive disorder; mdd; major depressive ... See more keywords
Disturbance of neurotransmitter metabolism in drug-naïve, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts
Sign Up to like & getrecommendations! Published in 2022 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-022-01406-8
Abstract: Neurotransmitter metabolism plays a critical role in the pathophysiology of major depressive disorder (MDD). However, whether the neurotransmitter metabolism in adolescent MDD is differentiated from adult MDD is still elusive. In the current study, plasma… read more here.
Keywords: first episode; adolescent; neurotransmitter metabolism; adult ... See more keywords