The Genetic Architecture of Major Depressive Disorder in Han Chinese Women
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2016.3578
Abstract: Importance Despite the moderate, well-demonstrated heritability of major depressive disorder (MDD), there has been limited success in identifying replicable genetic risk loci, suggesting a complex genetic architecture. Research is needed to quantify the relative contribution… read more here.
Keywords: risk; etiology; mdd; genetic architecture ... See more keywords
Risk of Posttraumatic Stress Disorder and Major Depression in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2018.4288
Abstract: Importance Traumatic brain injury (TBI) has been associated with adverse mental health outcomes, such as posttraumatic stress disorder (PTSD) and major depressive disorder (MDD), but little is known about factors that modify risk for these… read more here.
Keywords: risk; stress disorder; mdd; posttraumatic stress ... See more keywords
Community-Level Social Support Infrastructure and Adult Onset of Major Depressive Disorder in a South Asian Postconflict Setting.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2021.4052
Abstract: Importance Individual-level social support protects against major depressive disorder (MDD) among adults exposed to trauma. Little is known about the consequences of community-level interventions in the general population. Objective To determine the potential consequences of… read more here.
Keywords: level social; social support; population; infrastructure ... See more keywords
Evaluation of Prefrontal γ-Aminobutyric Acid and Glutamate Levels in Individuals With Major Depressive Disorder Using Proton Magnetic Resonance Spectroscopy.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.3384
Abstract: Importance Major depressive disorder (MDD) is one of the most prevalent illnesses worldwide. Perturbations of the major inhibitory and excitatory neurotransmitters, γ-aminobutyric acid (GABA) and glutamate (Glu), respectively, as well as Glx (Glu or glutamine… read more here.
Keywords: past mdd; glu; spectroscopy; healthy controls ... See more keywords
Large‐scale dynamic causal modeling of major depressive disorder based on resting‐state functional magnetic resonance imaging
Sign Up to like & getrecommendations! Published in 2020 at "Human Brain Mapping"
DOI: 10.1002/hbm.24845
Abstract: Major depressive disorder (MDD) is a serious mental illness characterized by dysfunctional connectivity among distributed brain regions. Previous connectome studies based on functional magnetic resonance imaging (fMRI) have focused primarily on undirected functional connectivity and… read more here.
Keywords: depressive disorder; network; mdd; major depressive ... See more keywords
Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder
Sign Up to like & getrecommendations! Published in 2020 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-020-01128-9
Abstract: Little is known about the pathophysiology of memory deficits in patients with major depressive disorder (MDD) treated with modified electroconvulsive therapy (MECT). This study examined the profiles of cytokines, the memory function, and their association… read more here.
Keywords: mdd patients; depressive disorder; mdd; major depressive ... See more keywords
Disturbance of neurotransmitter metabolism in drug-naïve, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts
Sign Up to like & getrecommendations! Published in 2022 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-022-01406-8
Abstract: Neurotransmitter metabolism plays a critical role in the pathophysiology of major depressive disorder (MDD). However, whether the neurotransmitter metabolism in adolescent MDD is differentiated from adult MDD is still elusive. In the current study, plasma… read more here.
Keywords: first episode; adolescent; neurotransmitter metabolism; adult ... See more keywords
Low left amygdala volume is associated with a longer duration of unipolar depression
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-017-1811-y
Abstract: The amygdala plays a crucial role in the pathogenesis of major depressive disorder (MDD). While robust findings support a negative impact of illness duration on hippocampal volume in MDD, morphometric studies of the amygdala have… read more here.
Keywords: volume; mdd; duration; gmv ... See more keywords
The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-05129-3
Abstract: Major depressive disorder (MDD) is considered a serious public health issue that adversely impacts an individual’s quality of life and contributes significantly to the global burden of disease. The clinical heterogeneity that exists among patients… read more here.
Keywords: depression; depressive disorder; unified model; mdd ... See more keywords
Hyperconnectivity between the posterior cingulate and middle frontal and temporal gyrus in depression: Based on functional connectivity meta-analyses.
Sign Up to like & getrecommendations! Published in 2022 at "Brain imaging and behavior"
DOI: 10.1007/s11682-022-00628-7
Abstract: Disrupted whole-brain resting-state functional connectivity (RSFC) of the posterior cingulate (PCC) has been highlighted to associate with cognitive and affective dysfunction in major depressive disorder (MDD). However, prior findings showed certain inconsistency about the RSFC… read more here.
Keywords: posterior cingulate; gyrus; functional connectivity; pcc ... See more keywords
High Risk of Depression in High-Income African American Boys
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Racial and Ethnic Health Disparities"
DOI: 10.1007/s40615-017-0426-1
Abstract: BackgroundDespite the well-established literature on the protective effect of socioeconomic status (SES) on physical and mental health, there are a few reports on poor mental health of blacks with high SES. Using a national sample,… read more here.
Keywords: risk; household income; mdd; day ... See more keywords