mDia1 senses both force and torque during F-actin filament polymerization
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DOI: 10.1038/s41467-017-01745-4
Abstract: Formins, an important family of force-bearing actin-polymerizing factors, function as homodimers that bind with the barbed end of actin filaments through a ring-like structure assembled from dimerized FH2 domains. It has been hypothesized that force… read more here.
Keywords: actin; actin polymerization; force; actin filament ... See more keywords
mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility
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DOI: 10.1371/journal.pbio.2004874
Abstract: Formin is one of the two major classes of actin binding proteins (ABPs) with nucleation and polymerization activity. However, despite advances in our understanding of its biochemical activity, whether and how formins generate specific architecture… read more here.
Keywords: continuous contractile; actin; actin meshwork; sertoli cells ... See more keywords