Shedding more light on the role of Midkine in hepatocellular carcinoma: New perspectives on diagnosis and therapy
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DOI: 10.1002/iub.2458
Abstract: One of the most common malignant tumors is hepatocellular carcinoma (HCC). Progression of HCC mainly results from highly complex molecular and pathological pathways. Midkine (MDK) is a growth factor that impacts viability, migration, and other… read more here.
Keywords: hepatocellular carcinoma; hcc; mdk; role ... See more keywords
The possible role of Dickkopf-1, Golgi protein- 73 and Midkine as predictors of hepatocarcinogenesis: a review and an Egyptian study
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DOI: 10.1038/s41598-020-62051-6
Abstract: Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. Therefore, we assessed the possible… read more here.
Keywords: golgi protein; mdk; possible role; mdk dkk ... See more keywords
Identification and validation of a poor clinical outcome subtype of primary prostate cancer with Midkine abundance
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DOI: 10.1111/cas.15546
Abstract: Recent studies identified Midkine (MDK) as playing a key role in immune regulation. In this study, we aimed to discover the clinical significance and translational relevance in prostate cancer (PCa). We retrospectively analyzed 759 PCa… read more here.
Keywords: prostate cancer; pca; expression; cancer ... See more keywords
Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins
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DOI: 10.3389/fonc.2022.885656
Abstract: IFN-γ is a pleiotropic cytokine with immunomodulatory and tumoricidal functions. It has been used as an anti-tumor agent in adjuvant therapies for various cancers. Paradoxically, recent advances have also demonstrated pro-tumorigenic effects of IFN-γ, especially… read more here.
Keywords: metastasis; cell line; ifn; cancer ... See more keywords
Combined Usage of MDK Inhibitor Augments Interferon-γ Anti-Tumor Activity in the SKOV3 Human Ovarian Cancer Cell Line
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DOI: 10.3390/biomedicines11010008
Abstract: Ovarian cancer (OC) is a particularly lethal disease due to intratumoral heterogeneity, resistance to traditional chemotherapy, and poor response to targeted therapy and immunotherapy. Interferon-γ (IFN-γ) is an attractive therapeutic cytokine, with positive responses achieved… read more here.
Keywords: metastasis; anti tumor; mdk inhibitor; ifn induced ... See more keywords
Midkine Is a Potential Therapeutic Target of Tumorigenesis, Angiogenesis, and Metastasis in Non-Small Cell Lung Cancer
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DOI: 10.3390/cancers12092402
Abstract: Hypoxia-inducible factors (HIFs) induced by reduced O2 availability activate the transcription of target genes encoding proteins that play important roles in communication between cancer and stromal cells. Cancer cells were incubated under hypoxic conditions: H1299,… read more here.
Keywords: hif; mdk; target; metastasis ... See more keywords