Anti-fibrotic effects of the sirt6-activator mdl-800 in cardiac stromal cells
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DOI: 10.1093/eurheartj/ehae666.3658
Abstract: Epigenetic changes are among the molecular substrates of cellular stress responses and tissue remodeling in heart failure progression. The sirtuin family of NAD+-dependent histone and non-histone protein deacetylases exert a protective anti-fibrotic role by negatively… read more here.
Keywords: mdl 800; tgfb1 ctr; ctr fold; tgfb1 ... See more keywords
MDL-800, the SIRT6 Activator, Suppresses Inflammation via the NF-κB Pathway and Promotes Angiogenesis to Accelerate Cutaneous Wound Healing in Mice
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DOI: 10.1155/2022/1619651
Abstract: Sirtuin 6 (SIRT6) is an NAD+-dependent deacetylase belonging to the sirtuin family. It has been shown to participate in wound healing and some inflammation-related disorders. However, the effect of MDL-800, a highly efficient and selective… read more here.
Keywords: inflammation; wound healing; mdl 800; sirt6 activator ... See more keywords