Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function
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DOI: 10.26508/lsa.202201472
Abstract: This study shows that MDM2 acidic and zinc finger regions weakly interact with the RING domain and a fragment of p14ARF strengthens this interaction to inhibit MDM2 ubiquitin ligase activity. ARF tumor suppressor protein is… read more here.
Keywords: interaction; mdm2; ring domain; activity ... See more keywords