Relevance of the p53–MDM2 axis to aging
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.187
Abstract: In response to varying stress signals, the p53 tumor suppressor is able to promote repair, survival, or elimination of damaged cells – processes that have great relevance to organismal aging. Although the link between p53… read more here.
Keywords: p53; p53 mdm2; mdm2 axis; relevance p53 ... See more keywords
Targeting the TP53/MDM2 axis enhances radiation sensitivity in atypical teratoid rhabdoid tumors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5322
Abstract: Atypical teratoid rhabdoid tumor (ATRT) is a highly aggressive pediatric brain tumor. Despite radiation, aggressive chemotherapy and autologous stem cell rescue, children usually have a poor survival time. In the present study, the role of… read more here.
Keywords: tp53 mdm2; mdm2; inhibition; tp53 ... See more keywords