MDM2 gene amplification as selection tool for innovative targeted approaches in PD-L1 positive or negative muscle-invasive urothelial bladder carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical pathology"
DOI: 10.1136/jclinpath-2020-207089
Abstract: AIMS According to The Cancer Genome Atlas (TCGA), around 9% of bladder carcinomas usually show abnormalities of the murine double minute 2 (MDM2) gene, but a few studies have been investigated them. We profiled MDM2… read more here.
Keywords: mdm2 gene; mdm2; muscle invasive; gene amplification ... See more keywords
MDM2 for the practicing pathologist: a primer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Pathology"
DOI: 10.1136/jcp-2022-208687
Abstract: The mouse double minute 2 (MDM2) gene is located on the long arm of chromosome 12 and is the primary negative regulator of p53. The MDM2 gene encodes an E3 ubiquitin–protein ligase that mediates the… read more here.
Keywords: mdm2; mdm2 gene; mdm2 practicing; practicing pathologist ... See more keywords
Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development Approach
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28072977
Abstract: An evaluation of the expression and predictive significance of the MDM2 gene in brain lower-grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several transcriptome servers were used to measure the differential expression of… read more here.
Keywords: gene; lgg cancer; mdm2 gene; bioactive phytochemicals ... See more keywords