Abstract 2606: Requirement of MDM2 E3 ligase activity for regulating p53 during normal development, cell cycle regulation and genome integrity
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DOI: 10.1158/1538-7445.am2023-2606
Abstract: p53 tumor suppressor, the most mutated gene in human cancer, is negatively regulated by MDM2 and MDM4 proteins. Two distinct mechanisms of MDM2/MDM4 regulation of p53 include, one, suppression of p53 transactivation activity by direct… read more here.
Keywords: mdm2 ligase; ligase activity; p53; regulation ... See more keywords