Anatomy of Mdm2 and Mdm4 in evolution
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjx002
Abstract: Abstract Mouse double minute (Mdm) genes span an evolutionary timeframe from the ancient eukaryotic placozoa Trichoplax adhaerens to Homo sapiens, implying a significant and possibly conserved cellular role throughout history. Maintenance of DNA integrity and… read more here.
Keywords: p53; anatomy; mdm2 mdm4; evolution ... See more keywords
Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.933446
Abstract: MDM2 and MDM4 proteins are key negative regulators of tumor suppressor p53. MDM2 and MDM4 interact via their RING domains and form a heterodimer polyubiquitin E3 ligase essential for p53 degradation. MDM4 also forms heterodimer… read more here.
Keywords: mdm4; apoptosis; mdm2 mdm4; p53 ... See more keywords
Sex-Specific Associations of MDM2 and MDM4 Variants with Risk of Multiple Primary Melanomas and Melanoma Survival in Non-Hispanic Whites
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15102707
Abstract: Simple Summary Melanoma is the most severe type of skin cancer, and the risk of developing melanoma and of dying of melanoma varies between women and men. This study investigated whether widely studied genetic single… read more here.
Keywords: mdm2; melanoma; mdm2 mdm4; risk ... See more keywords