Calculation of hot spots for protein–protein interaction in p53/PMI‐MDM2/MDMX complexes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.25592
Abstract: The recently developed MM/GBSA_IE method is applied to computing hot and warm spots in p53/PMI‐MDM2/MDMX protein–protein interaction systems. Comparison of the calculated hot (>2 kcal/mol) and warm spots (>1 kcal/mol) in P53 and PMI proteins… read more here.
Keywords: mdm2 mdmx; p53 pmi; mdmx;
Bicyclic stapled peptides based on p53 as dual inhibitors for the interactions of p53 with MDM2 and MDMX
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2021.08.130
Abstract: ABSTRACT In recent years, the strategy of inhibiting the interactions of p53 with murine double minute 2 (MDM2) and murine double minute X (MDMX) has been proved to be a promising approach for tumor therapy.… read more here.
Keywords: mdm2 mdmx; stapled peptides; p53; bicyclic stapled ... See more keywords
Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.26768
Abstract: Background Genetic factors play a substantial role in breast cancer etiology. Genes encoding proteins that have key functions in the DNA damage response, such as p53 and its inhibitors MDM2 and MDMX, are most likely… read more here.
Keywords: mdm2 mdmx; log rank; breast; breast cancer ... See more keywords
Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.75444
Abstract: Rationale: Although stapled peptides offer a powerful solution to overcome the susceptibility of linear peptides to proteolytic degradation and improve their ability to cross membranes, an efficient and durable disease treatment strategy has not yet… read more here.
Keywords: peptide based; mdm2 mdmx; stapled peptide; atypical degradation ... See more keywords