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Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30940
Abstract: Cyclo‐glycylproline (cGP), a cyclic dipeptide containing a condensation bond between glycine and proline, is produced by the cyclization of the N‐terminal tripeptide of insulin‐like growth factor‐1. Previous studies have shown that cGP administration exerts a…
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Keywords:
cgp;
damage;
oxidative stress;
brain ... See more keywords
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1
Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01945
Abstract: MDM2 is a key oncogenic protein that serves as a negative regulator of the tumor suppressor p53. While a number of inhibitors of the MDM2-p53 interaction have progressed to clinical testing as treatments for a…
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Keywords:
improve efficacy;
mdm2 p53;
targeted degradation;
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2
Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00112
Abstract: Human exposure to fenpropathrin, a widely used pesticide, is linked to Parkinson's-like symptoms in the body. However, a specific pathogenic mechanism is still unclear. This study found that fenpropathrin increased the expression of murine double…
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Keywords:
mdm2;
p53 pathway;
secretion;
p53 ... See more keywords
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1
Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2016.159
Abstract: Mutations resulting in constitutive activation of signaling pathways that regulate ribosome biogenesis are among the most common genetic events in acute myeloid leukemia (AML). However, whether ribosome biogenesis presents as a therapeutic target to treat…
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Keywords:
induction;
mdm2 p53;
rnp mdm2;
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Published in 2022 at "Toxicology research"
DOI: 10.1093/toxres/tfac016
Abstract: Nonylphenol (NP) is an endocrine disrupting chemical, which widely exists in environment and can result in multiple system dysfunction. Pancreas as one of the most important organs is sensitive to NP, while the detail toxic…
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Keywords:
dysfunction;
p53 p21;
mdm2 p53;
p21 axis ... See more keywords
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1
Published in 2017 at "Science Advances"
DOI: 10.1126/sciadv.1701383
Abstract: The unspliced form of XBP1 stabilizes MDM2 protein by inhibiting its ubiquitination and regulates the MDM2/p53 axis. Cell cycle progression is a tightly controlled fundamental process in living cells, with any defects being closely linked…
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Keywords:
p53 axis;
p53;
regulator;
mdm2 p53 ... See more keywords
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1
Published in 2022 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00434-21
Abstract: Posttranslational histone modifications play important roles in regulating chromatin structure and transcriptional regulation. Histone H2B monoubiquitination (H2Bub) is an essential regulator for transcriptional elongation and ongoing transcription. ABSTRACT Posttranslational histone modifications play important roles in…
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Keywords:
cell proliferation;
mdm2;
histone h2b;
hct116 cell ... See more keywords
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1
Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4344677
Abstract: Doxorubicin (DOX), the anthracycline chemotherapeutic agent, is widely used for the treatment of various cancers. However, its clinical application is compromised by dose-dependent and fatal cardiotoxicity. This study is aimed at investigating the cardioprotective effects…
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Keywords:
mitochondrial biogenesis;
mitophagy mitochondrial;
cardiotoxicity;
p53 ... See more keywords
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0
Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-4190
Abstract: Robust function of the p53 tumor suppressor pathway is critical when treating with DNA-damage inducing agents such as radiation therapy (RT), which is a key component of standard care for GBM. MDM2 is an important…
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Keywords:
antagonist mdm2;
mdm2;
penetrant mdm2;
p53 antagonist ... See more keywords
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3
Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb003
Abstract: The E3 ligase MDM2 controls the tumor suppressor function of p53, which is encoded by the TP53gene. Compounds designed to bind to MDM2 preventing its interaction with p53 restore the ability of p53 to combat…
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Keywords:
highly potent;
mdm2;
907828 highly;
potent mdm2 ... See more keywords
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Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22543
Abstract: p53 is a tumour suppressor that is activated in response to various types of stress. It is regulated by a complex pattern of over 50 different post-translational modifications, including ubiquitination by the E3 ligase MDM2,…
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Keywords:
inhibitory effects;
activity;
btk;
p53 ... See more keywords