Abstract A23: Mdm2 phosphorylation by Akt is critical for modulating cellular responses to oxidative stress
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DOI: 10.1158/1538-7445.mousemodels17-a23
Abstract: The serine/threonine kinase Akt is activated by a myriad of growth signals and promotes cell proliferation, survival, and metabolism. Akt is frequently activated in a wide assortment of human hematologic malignancies and solid tumors. In… read more here.
Keywords: p53; stress; mdm2 phosphorylation; oxidative stress ... See more keywords
p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors
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DOI: 10.3390/cancers15010121
Abstract: Simple Summary p90RSK is a downstream effector protein of the MAPK pathway. In many human cancers, the MAPK pathway is constitutively activated due to oncogenic mutations of its components. Consequently, p90RSK is hyperactive and capable… read more here.
Keywords: mdm2 phosphorylation; p53 pathway; thyroid tumors; p90rsk ... See more keywords